Evidence map›Paper›PMID 39638759›Full record

ArticleGeriatrics & gerontology international2025

Astragaloside IV inhibits vascular calcification through estrogen receptor alpha.

Michiko Nanao-Hamai, Bo-Kyung Son, Sumito Ogawa, Masahiro Akishita

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Geriatrics & gerontology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michiko Nanao-HamaiDepartment of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0009-0007-1375-4169
Bo-Kyung SonInstitute of Gerontology, The University of Tokyo, Tokyo, Japan.
Sumito OgawaDepartment of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-5935-276X
Masahiro AkishitaDepartment of Functional Biogerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.ORCID https://orcid.org/0000-0001-5498-7224

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astragaloside IV (As-IV), a key component of traditional Japanese Hozai tonics, has a steroid skeleton like estrogen. It inhibits vascular calcification via estrogen receptor α, offering cardiovascular benefits. However, its estrogen-like properties promote breast cancer cell proliferation. Targeted research is needed to optimize cardiovascular preventive effects without adverse effects.

Indexed as

Estrogen Receptor alphaSaponinsTriterpenesVascular CalcificationAnimalsFemaleHumansastragaloside AEstrogen Receptor alphaSaponinsTriterpenes

Identifiers

PMID39638759
PMCPMC11711066

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.