Evidence map›Paper›PMID 39638608›Full record

ArticleBMJ global health2024

Contribution of malnutrition to infant and child deaths in Sub-Saharan Africa and South Asia.

Zachary J Madewell, Adama Mamby Keita, Priya Mehta-Gupta Das, Ashka Mehta, Victor Akelo, Ogony Benard Oluoch, Richard Omore, Dickens Onyango, Caleb K Sagam, Carrie Jo Cain and 33 more

Abstract read
In one paragraph

Article in BMJ global health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Zachary J MadewellGlobal Health Center, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID http://orcid.org/0000-0002-5667-9660
Adama Mamby KeitaCentre pour le Développement des Vaccins, Ministère de la Santé, Bamako, Mali.
Priya Mehta-Gupta DasRollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID http://orcid.org/0000-0002-9670-5595
Ashka MehtaCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Victor AkeloUS Centers for Disease Control and Prevention, Kisumu, Kenya.
Ogony Benard OluochKenya Medical Research Institute, Nairobi, Nairobi County, Kenya.
Richard OmoreKenya Medical Research Institute, Nairobi, Nairobi County, Kenya.
Dickens OnyangoKisumu County Department of Health, Kisumu, Nyanza, Kenya.
Caleb K SagamKenya Medical Research Institute, Nairobi, Nairobi County, Kenya.
Carrie Jo CainWorld Hope International, Freetown, Sierra Leone.
Cornell ChukwuegboFederal Medical Centre, Umuahia, Nigeria.
Erick KalumaCrown Agents, Freetown, Sierra Leone.
Ronita LukeMinistry of Health and Sanitation, Freetown, Sierra Leone.
Ikechukwu Udo OgbuanuCrown Agents, Freetown, Sierra Leone.
Quique BassatISGlobal-Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0003-0875-7596
Milton KincardettCentro de Investigação em Saúde de Manhiça-CISM, Manhica, Maputo, Mozambique.
Inacio MandomandoISGlobal-Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-1078-2187
Natalia RakislovaISGlobal-Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-5030-3526
Rosauro VaroISGlobal-Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
Elisio G XerindaCentro de Investigação em Saúde de Manhiça-CISM, Manhica, Maputo, Mozambique.
Ziyaad DangorSouth African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Jeanie du ToitSouth African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Sanjay G LalaDepartment of Paediatrics & Child Health, University of the Witwatersrand, Johannesburg, South Africa.
Shabir A MadhiSouth African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Sana MahtabSouth African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Markus Roos BreinesDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Ketema DegefaCollege of Health and Medical Sciences, Haramaya University, Dire Dawa, Ethiopia.
Helina HelufCollege of Health and Medical Sciences, Haramaya University, Dire Dawa, Ethiopia.
Lola MadridDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.ORCID http://orcid.org/0000-0003-4034-6033
J Anthony G ScottKenya Medical Research Institute, Nairobi, Nairobi County, Kenya.
Samba O SowCentre pour le Développement des Vaccins, Ministère de la Santé, Bamako, Mali.
Milagritos D TapiaCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Shams El ArifeenInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
Emily S GurleyInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
Mohammad Zahid HossainInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
Kazi Munisul IslamInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
Afruna RahmanInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
Portia C MutevedziEmory Global Health Institute, Emory University, Atlanta, Georgia, USA.
Cynthia G WhitneyEmory Global Health Institute, Emory University, Atlanta, Georgia, USA.
Dianna M BlauGlobal Health Center, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Parminder S SuchdevGlobal Health Center, Centers for Disease Control and Prevention, Atlanta, Georgia, USA psuchde@emory.edu.
Karen L KotloffCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Child Health and Mortality Prevention Surveillance Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMalnutrition contributes to 45% of all childhood deaths globally, but these modelled estimates lack direct measurements in countries with high malnutrition and under-5 mortality rates. We investigated malnutrition's role in infant and child deaths in the Child Health and Mortality Prevention Surveillance (CHAMPS) network.

methodsWe analysed CHAMPS data from seven sites (Bangladesh, Ethiopia, Kenya, Mali, Mozambique, Sierra Leone and South Africa) collected between 2016 and 2023. An expert panel assessed each death to determine whether malnutrition was an underlying, antecedent or immediate cause or other significant condition. Malnutrition was further classified based on postmortem anthropometry using WHO growth standards for underweight (z-scores for weight-for-age <-2), stunting (length-for-age <-2), and wasting (weight-for-length or MUAC Z-scores <-2).

resultsOf 1601 infant and child deaths, malnutrition was considered a causal or significant condition in 632 (39.5%) cases, including 85 (13.4%) with HIV infection. Postmortem measurements indicated 90.1%, 61.2% and 94.1% of these cases were underweight, stunted and wasted, respectively. Most malnutrition-related deaths (n=632) had an infectious cause (89.1%). The adjusted odds of having malnutrition as causal or significant condition were 2.4 (95% CI 1.7 to 3.2) times higher for deaths involving infectious diseases compared with other causes. Common pathogens in the causal pathway for malnutrition-related deaths included

conclusionMalnutrition was identified as a causal or significant factor in 39.5% of under-5 deaths in the CHAMPS network, often in combination with infectious diseases. These findings highlight the need for integrated interventions addressing both malnutrition and infectious diseases to effectively reduce under-5 mortality.

Indexed as

Child MortalityAfrica South of the SaharaAsia, SouthernCause of DeathChild Nutrition DisordersChild, PreschoolFemaleHumansInfantInfant MortalityInfant, NewbornMaleMalnutritionChild healthEpidemiologyGlobal HealthNutritionPaediatrics

Identifiers

PMID39638608
PMCPMC11624724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.