Evidence map›Paper›PMID 39638605›Full record

ArticleEmerging microbes & infections2024

Identification of cepharanthine as an effective inhibitor of African swine fever virus replication.

Chuanxiang Qi, Jiyoung Lee, Yongqiang Zhang, Huan Chen, Jiaxuan Lv, Zhenzhong Wang, Jinming Li, Xiaodong Wu, Yong-Sam Jung, Zhiliang Wang and 1 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. InactivatedFrontiers in immunology · 2025
    Article
  5. Virus infection and vesicle trafficking.Frontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chuanxiang QiOne Health Laboratory, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People's Republic of China.
Jiyoung LeeOne Health Laboratory, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People's Republic of China.
Yongqiang ZhangChina Animal Health and Epidemiology Center, Qingdao, People's Republic of China.
Huan ChenOne Health Laboratory, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People's Republic of China.
Jiaxuan LvOne Health Laboratory, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People's Republic of China.
Zhenzhong WangOne Health Laboratory, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People's Republic of China.
Jinming LiChina Animal Health and Epidemiology Center, Qingdao, People's Republic of China.
Xiaodong WuChina Animal Health and Epidemiology Center, Qingdao, People's Republic of China.
Yong-Sam JungOne Health Laboratory, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People's Republic of China.
Zhiliang WangChina Animal Health and Epidemiology Center, Qingdao, People's Republic of China.
Yingjuan QianOne Health Laboratory, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

African swine fever virus (ASFV) causes highly contagious swine disease, African swine fever (ASF), thereby posing a severe socioeconomic threat to the global pig industry and underscoring that effective antiviral therapies are urgently required. To identify safe and efficient anti-ASFV compounds, a natural compound library was screened by performing an established cell-based ELISA in an ASFV-infected porcine alveolar macrophage (PAM) model. In total, 6 effective anti-ASFV compounds with low cytotoxicity were identified. Cepharanthine (CEP), a bisbenzylisoquinoline alkaloid, was the most potent inhibitor effect with an IC

Indexed as

African Swine FeverAfrican Swine Fever VirusAntiviral AgentsBenzylisoquinolinesVirus InternalizationVirus ReplicationAnimalsBenzodioxolesGene Expression ProfilingMacrophages, AlveolarSwineAntiviral AgentsBenzodioxolesBenzylisoquinolinescepharanthineAfrican swine fever viruscepharanthinecholesterol biosynthesisEHD2transcriptome analysis

Identifiers

PMID39638605
PMCPMC11622385

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.