Evidence map›Paper›PMID 39638433›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Quantitative Accuracy Assessment of the NeuroEXPLORER for Diverse Imaging Applications: Moving Beyond Standard Evaluations.

Negar Omidvari, Ekaterina Shanina, Edwin K Leung, Xishan Sun, Yusheng Li, Tim Mulnix, Paul Gravel, Shannan Henry, David Matuskey, Tommaso Volpi and 6 more

2 registry-linked trialsAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07509125 narecruitingnot on this mapstarted 2026, after this paper: background citation

Ultra-High Resolution PET of the Human Brain and Spinal Cord in Healthy Aging, Dementia, Movement Disorders, ALS and Psychotic Disorders

TypeinterventionalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2026 to 2029Enrolled300ConditionsAlzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis, Parkinson s Disease, REM Sleep Behavior Disorder (iRBD)ArmsUHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain with ¹⁸F-SynVesT-1, UHR PET/CT scan of the brain with ¹⁸F-MK6240, 3T MRI imaging of the brain
NCT07595666 naenrolling by invitationnot on this map

Prospective Comparison of Ultra-high Resolution NeuroExplorer PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region

TypeinterventionalSponsorprof. dr. Koen Van LaereRan2025 to 2030Enrolled1,600ConditionsDementia, Movement Disorders, ALS - Amyotrophic Lateral Sclerosis, EpilepsyArmsStandard-of-care PET/CT, NeuroEXPLORER
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. SV2A PET Imaging Detects Severity-Dependent Synaptic Changes After Experimental Traumatic Spinal Cord Injury.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  4. Article
  5. High-resolution in utero SV2A PET imaging of the nonhuman primate brain using the NeuroEXPLORER.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  6. Eagle eyes on the human brain and beyond: PET at ultra-high spatial resolution.European journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Article
  8. Article
  9. Development and Initial Evaluation of 3D-printed High Resolution Brain Phantom for PET.IEEE transactions on radiation and plasma medical sciences · 2025
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Negar OmidvariDepartment of Biomedical Engineering, University of California Davis, Davis, California; nomidvari@ucdavis.edu.
Ekaterina ShaninaDepartment of Biomedical Engineering, University of California Davis, Davis, California.
Edwin K LeungUnited Imaging Healthcare America, Houston, Texas.
Xishan SunUnited Imaging Healthcare America, Houston, Texas.
Yusheng LiUnited Imaging Healthcare America, Houston, Texas.
Tim MulnixDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut; and.
Paul GravelDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut; and.
Shannan HenryDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut; and.
David MatuskeyDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut; and.
Tommaso VolpiDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut; and.
Terry JonesDepartment of Radiology, University of California Davis Medical Center, Sacramento, California.
Ramsey D BadawiDepartment of Radiology, University of California Davis Medical Center, Sacramento, California.
Hongdi LiUnited Imaging Healthcare America, Houston, Texas.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut; and.
Jinyi QiDepartment of Biomedical Engineering, University of California Davis, Davis, California.
Simon R CherryDepartment of Biomedical Engineering, University of California Davis, Davis, California.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NeuroExplorer: Ultra-high Performance Human Brain PET Imager for Highly-resolved In Vivo Imaging of NeurochemistryU01EB029811 · NIBIB · YALE UNIVERSITY · PI CARSON, RICHARD E., LI, HONGDI · 2020 to 2024
$10.0M
NCATS NIH HHS UL1 TR001863NIBIB NIH HHS U01 EB029811
6 · The paper itself

Abstract

Quantitative molecular imaging with PET can offer insights into physiologic and pathologic processes and is widely used for studying brain disorders. The NeuroEXPLORER is a recently developed dedicated brain PET system offering high spatial resolution and high sensitivity with an extended axial length. This study evaluated the quantitative precision and accuracy of the NeuroEXPLORER with phantom and human data for a variety of imaging conditions that are relevant to dynamic neuroimaging studies.

Indexed as

BrainPhantoms, ImagingPositron-Emission TomographyFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedNeuroimagingFluorodeoxyglucose F18brain PETNeuroEXPLORERquantification

Identifiers

PMID39638433
PMCPMC11705792

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.