ArticleNeuroImage2025
Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression.
Article in NeuroImage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Subcallosal cingulate functional connectivity in depression: a systematic review of brain stimulation-induced changes and pretreatment connectivity predictors.Translational psychiatry · 2026Pooled it
- Causal connectivity maps derived from single-pulse interleaved TMS/fMRI.Scientific reports · 2026Trial
- Low-intensity transcranial focused ultrasound amygdala neuromodulation: a double-blind sham-controlled target engagement study and unblinded single-arm clinical trial.Molecular psychiatry · 2025Trial
- Intrinsic functional architecture predicts remote motor cortical excitability changes induced by intermittent theta-burst stimulation.iScience · 2026Article
- Mixed reality assisted target localization for transcranial magnetic stimulation navigation: a feasibility study.Journal of neuroengineering and rehabilitation · 2026Article
- White matter pathways mediating dorsolateral prefrontal TMS therapy for depression.Nature neuroscience · 2026Article
- Functional inputs to the subgenual cingulate cortex differentiate levels of depressive symptom severity in neurotypical young adults: granger causality and clustering analyses.The international journal of neuropsychopharmacology · 2026Article
- Article
- Heart-Brain Axis Dysregulation in Depression: Mechanisms and Implications for Neuromodulation.Neuropsychiatric disease and treatment · 2026Review
- Unveiling the Multifaceted Networks of the Left DLPFC for Precision TMS Targeting.bioRxiv : the preprint server for biology · 2025Article
- Circuit-Based Approaches to Understanding the Anterior Cingulate Cortex (ACC).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Response prediction for repetitive transcranial magnetic stimulation treatment.Current opinion in psychiatry · 2025Review
- Causal Connectivity Maps Derived from Single-Pulse Interleaved TMS/fMRI.Research square · 2025Article
- Efficacy and Safety of Transcranial Magnetic Stimulation for Treating Late-Life Depression: A Scoping Review.Journal of clinical medicine · 2025Review
- Precision TMS through the integration of neuroimaging and machine learning: optimizing stimulation targets for personalized treatment.Frontiers in human neuroscience · 2025Review
- The RF Cap: A 26-channel flexible RF coil cap for optimized concurrent TMS/fMRI experiments at 3T.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Dorsolateral prefrontal cortex TMS evokes responses in the subgenual anterior cingulate cortex: Evidence from human intracranial EEG.bioRxiv : the preprint server for biology · 2024Article
- Elevating the field for applying neuroimaging to individual patients in psychiatry.Translational psychiatry · 2024Review
- Intermittent theta burst stimulation with synchronised transcranial alternating current stimulation leads to enhanced frontal theta oscillations and a positive shift in emotional bias.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Non-Invasively Targeting, Probing, and Modulating a Deep Brain Circuit for Depression Alleviation.Nature. Mental health · 2023Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundDepression alleviation following treatment with repetitive transcranial magnetic stimulation (rTMS) tends to be more effective when TMS is targeted to cortical areas with high (negative) resting state functional connectivity (rsFC) with the subgenual anterior cingulate cortex (sgACC). However, the relationship between sgACC-cortex rsFC and the TMS-evoked response in the sgACC is still being explored and has not yet been established in depressed patients.
objectivesIn this study, we investigated the relationship between sgACC-cortical (site of stimulation) rsFC and induced evoked responses in the sgACC in healthy controls and depressed patients.
methodsFor each participant (N = 115, 34 depressed patients), a peak rsFC cortical 'hotspot' for the sgACC and control targets were identified at baseline. Single pulses of TMS interleaved with fMRI readouts were administered to these targets to evoke downstream fMRI blood-oxygen-level-dependent (BOLD) responses in the sgACC. Generalized estimating equations were used to investigate the association between TMS-evoked BOLD responses in the sgACC and rsFC between the stimulation site and the sgACC.
resultsStimulations over cortical sites with high rsFC to the sgACC were effective in modulating activity in the sgACC in both healthy controls and depressed patients. Moreover, we found that in depressed patients, sgACC rsFC at the site of stimulation was associated with the induced evoked response amplitude in the sgACC: stronger positive rsFC values leading to stronger evoked responses in the sgACC.
conclusionsrsFC-based targeting is a viable strategy to causally modulate the sgACC. Assuming an anti-depressive mechanism working through modulation of the sgACC, the field's exclusive focus on sites anticorrelated with the sgACC for treating depression should be broadened to explore positively-connected sites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.