ArticleEnvironmental research2025
The environmental neuroactive chemicals list of prioritized substances for human biomonitoring and neurotoxicity testing: A database and high-throughput toxicokinetics approach.
Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
There is a diversity of chemicals to which humans are potentially exposed. Few of these chemicals have linked human biomonitoring data, and most have very limited neurotoxicity testing. Of particular concern are environmental exposures impacting children, who constitute a population of heightened susceptibility due to rapid neural growth and plasticity, yet lack biomonitoring data compared to other age/population subgroups. This study set out to develop a prioritized list of neuroactive substances, titled the Environmental NeuRoactIve CHemicals (ENRICH) list, to be used as a defined screening library in the evaluation of human biological samples, with emphasis on early childhood-relevant environmental exposures. In silico database mining approaches were used to prioritize chemicals based upon likelihood of neuroactivity, human exposure, and feasible detection in biological samples. Evidence of neuroactivity was compiled across in vitro high-throughput screening, animal testing, and/or human epidemiological findings. Chemicals were considered for their likelihood of human exposure and detection presence in biological samples (including metabolites), with additional evidence indicating presence within child-relevant products. The resulting list of 1827 chemicals were ranked using a Chemical Prioritization Index. Manual inclusion/exclusion criteria were employed for the top-ranking chemical candidates to ensure that chemicals were within the study's scope (i.e., environmentally relevant) and, for the purposes of biomonitoring, had properties amenable to mass spectrometry methods. These elements were combined to produce the ENRICH list of 250 top-ranking chemicals, spanning pesticides and those used in home maintenance, personal care, cleaning products, vehicles, arts and crafts, and consumer electronics, among other sources. Chemicals were additionally evaluated for high-throughput toxicokinetics to predict how much of a chemical and/or its metabolite(s) may reach urine, as an example biological matrix for practical use in biomonitoring efforts. This novel study couples databases and in silico-based predictions to prioritize chemicals in the environment with potential neurological impacts for future study.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.