ReviewMolecules and cells2025
Biological functions and molecular mechanisms of MORC2 in human diseases.
Review in Molecules and cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Molecules and Cells 2025, highlights from molecules to organisms.Molecules and cells · 2026Article
- Targeting MORC2 activates transposable element-mediated viral mimicry and potentiates immune checkpoint blockade in triple-negative breast cancer.Molecular cancer · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microrchidia family CW-type zinc finger 2 (MORC2) is a nuclear protein that has been highly conserved throughout evolution. MORC2 consists of an ATPase domain at the N-terminus, a CW-type zinc finger domain in the middle, and coiled-coil domains at the C-terminus. MORC2 is involved in various important biological processes such as transcriptional regulation, chromatin remodeling, DNA damage repair, and metabolism. Recent studies suggest that MORC2 may serve as a potential biomarker and therapeutic target for hereditary neurological diseases and cancers. However, the exact molecular functions and pathogenic mechanisms of MORC2 in human diseases remain to be explored. In this review, we provide an overview of recent advancements in understanding the molecular functions of MORC2, as well as the characteristics and mechanisms of MORC2-related diseases, which will be valuable for future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.