Evidence map›Paper›PMID 39637865›Full record

ArticleStructure (London, England : 1993)2025

Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease.

Peter Rory Hall, Thibault Jouen-Tachoire, Marcus Schewe, Peter Proks, Thomas Baukrowitz, Elisabeth P Carpenter, Simon Newstead, Karin E J Rödström, Stephen J Tucker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Structure (London, England : 1993), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Structural basis for proton inhibition of the two-pore domain KStructure (London, England : 1993) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Structure of the human TWIK-2 potassium channel and its inhibition by pimozide.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peter Rory HallDepartment of Biochemistry, University of Oxford, Oxford, UK; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; Scripps Institute, San Diego, CA, USA; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.
Thibault Jouen-TachoireClarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; Department of Pharmacology, University of Oxford, Oxford, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK.
Marcus ScheweInstitute of Physiology, Kiel University, Kiel, Germany.
Peter ProksClarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.
Thomas BaukrowitzInstitute of Physiology, Kiel University, Kiel, Germany.
Elisabeth P CarpenterCentre for Medicines Discovery, University of Oxford, Oxford, UK.
Simon NewsteadDepartment of Biochemistry, University of Oxford, Oxford, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.
Karin E J RödströmDepartment of Biochemistry, University of Oxford, Oxford, UK; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. Electronic address: karin.rodstrom@bioch.ox.ac.uk.
Stephen J TuckerClarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. Electronic address: stephen.tucker@physics.ox.ac.uk.

Funding

Wellcome Trust 215519Wellcome Trust 219531
6 · The paper itself

Abstract

TASK-1 and TASK-3 are pH-sensitive two-pore domain (K2P/KCNK) K

Indexed as

Cryoelectron MicroscopyIon Channel GatingNerve Tissue ProteinsPotassium Channels, Tandem Pore DomainHEK293 CellsHumansModels, MolecularMutation, MissenseShal Potassium ChannelsKCND3 protein, humanKCNK9 protein, humanNerve Tissue ProteinsPotassium Channels, Tandem Pore Domainpotassium channel subfamily K member 3Shal Potassium ChannelsBirk Barel SyndromechannelopathycryoEMK2P channelKCNK3KCNK9TASK channels

Identifiers

PMID39637865
PMCPMC7617898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.