Evidence map›Paper›PMID 39637835›Full record

ArticleNeuron2024

Genetic risk factors for late-onset Alzheimer's disease drive senescence in female tauopathy mice.

Tiffany Hensley-McBain, Miranda E Orr

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Senescent brain cell types in Alzheimer's disease: Pathological mechanisms and therapeutic opportunities.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Tiffany Hensley-McBainMcLaughlin Research Institute, Great Falls, MT 59405, USA; Touro College of Osteopathic Medicine, Great Falls, MT 59405, USA.
Miranda E OrrDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; St. Louis VA Medical Center, St. Louis, MO, USA. Electronic address: orr.m@wustl.edu.

Funding

High Resolution Profiling of Senescent Neurons and Their Microenvironments in Postmortem Human Brain Tissue Spanning Eight Decades of LifeR01AG068293 · NIA · WASHINGTON UNIVERSITY · PI ORR, MIRANDA ETHEL · 2020 to 2025
$2.0M
BLRD VA I01 BX005717NIA NIH HHS R01 AG068293
6 · The paper itself

Abstract

Carling et al. report that late-onset Alzheimer's disease (LOAD) risk alleles drive cellular senescence, a hallmark of aging, in a tau- and sex-dependent manner. Mechanistic insights into interactions among genetic risk, biological aging, and sex differences in LOAD are presented.

Indexed as

Alzheimer DiseaseTauopathiesAgingAnimalsCellular SenescenceDisease Models, AnimalFemaleHumansMaleMiceMice, TransgenicRisk FactorsSex Characteristicstau Proteinstau Proteins

Identifiers

PMID39637835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.