Evidence map›Paper›PMID 39637519›Full record

ArticleNeurobiology of aging2025

Locus coeruleus MRI contrast, cerebral perfusion, and plasma Alzheimer's disease biomarkers in older adults.

Shubir Dutt, Shelby L Bachman, Martin J Dahl, Yanrong Li, Belinda Yew, Jung Yun Jang, Jean K Ho, Kaoru Nashiro, Jungwon Min, Hyun Joo Yoo and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Shubir DuttDepartment of Psychology, University of Southern California, Los Angeles, CA, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Shelby L BachmanLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Martin J DahlLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Yanrong LiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Belinda YewIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Jung Yun JangInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Jean K HoInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Kaoru NashiroLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Jungwon MinLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Hyun Joo YooLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Aimée GaubertLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Amy NguyenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Anna E BlankenDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA; San Francisco Veterans Affairs Health Care System, CA, USA.
Isabel J SibleDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Anisa J MarshallDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Arunima KapoorDepartment of Psychological Science, University of California, Irvine, CA, USA.
John Paul M AlitinLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Kim HoangInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Jeremy RouanetDepartment of Pathology & Laboratory Medicine, University of California, Irvine, CA, USA.
Lorena SordoDepartment of Pathology & Laboratory Medicine, University of California, Irvine, CA, USA.
Elizabeth HeadDepartment of Pathology & Laboratory Medicine, University of California, Irvine, CA, USA.
Xingfeng ShaoLaboratory of FMRI Technology, Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, CA, Los Angeles, USA.
Danny J J WangLaboratory of FMRI Technology, Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, CA, Los Angeles, USA.
Mara MatherLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Daniel A NationLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA; Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, CA, Los Angeles, USA. Electronic address: danation@usc.edu.

Funding

Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mathew Mark Blurton-Jones · 2020 to 2026
$27.9M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
RESEARCH TRAINING IN GERONTOLOGYT32AG000037 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, EILEEN M CRIMMINS · 1985 to 2026
$13.2M
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineR01AG082073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONDI, MARK W, MATHER, MARA · 2023 to 2025
$4.9M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
Why Does Heart Rate Variability Matter for Emotion RegulationR01AG057184 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MATHER, MARA · 2017 to 2021
$2.1M
NIA NIH HHS P01 AG052350NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG057184NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228NIA NIH HHS R01 AG082073NIA NIH HHS T32 AG000037
6 · The paper itself

Abstract

The locus coeruleus (LC) is among the first brain structures impacted by Alzheimer's disease (AD), and noradrenergic denervation may contribute to early neurovascular dysfunction in AD. Mechanistic links between the LC and cerebral perfusion have been demonstrated in rodents, but there have been no similar studies in aging humans. Community-dwelling older adults with no history of stroke or dementia (N=66) underwent structural (T1-MPRAGE; T1-FSE) and perfusion (resting pCASL) MRI. Plasma AD biomarkers levels were evaluated for Aβ42/40 ratio (n=56) and pTau181 (n=60). Higher rostral LC structural MRI contrast was associated with lower perfusion in entorhinal and limbic regions but higher perfusion in lateral and medial orbitofrontal cortices. Relationships between LC structure and regional cerebral perfusion were attenuated in older adults with higher plasma pTau levels and lower plasma Aβ42/40 ratios. Previously unstudied links between LC structure and cerebral perfusion are detectible in older adults using MRI and are attenuated in those showing greater AD pathophysiologic change, suggesting an uncoupling of LC-cerebral perfusion relationships in older adults with aggregating AD-related pathophysiology.

Indexed as

AgingAlzheimer DiseaseCerebrovascular CirculationLocus CoeruleusMagnetic Resonance ImagingAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersFemaleHumansMalePeptide Fragmentstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)BiomarkersPeptide Fragmentstau ProteinsAlzheimer’s diseasecerebral blood flowlocus coeruleusolder adultsplasma biomarkers

Identifiers

PMID39637519
PMCPMC11781958

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.