Evidence map›Paper›PMID 39636981›Full record

ArticleScience (New York, N.Y.)2024

A conserved bacterial genetic basis for commensal-host specificity.

Karina Gutiérrez-García, Kevin Aumiller, Ren Dodge, Benjamin Obadia, Ann Deng, Sneha Agrawal, Xincheng Yuan, Richard Wolff, Haolong Zhu, Ru-Ching Hsia and 2 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Gut microbiota promote early-life digestive function in songbirds.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Environment and diet shape the geography-specificApplied and environmental microbiology · 2025
    Article
  10. Is it time to assignApplied and environmental microbiology · 2025
    Article
  11. Evolution and ecology of commensal gut protists: recent advances.Current opinion in genetics & development · 2025
    Review
  12. Review
  13. Microbiome evolution plays a secondary role in host rapid adaptation.bioRxiv : the preprint server for biology · 2025
    Article
  14. Infection and immunity · 2025
    Review
  15. Commensals find their niche.Nature reviews. Microbiology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Karina Gutiérrez-García *Biosphere Sciences and Engineering Division, Carnegie Institution for Science, Baltimore, MD, USA.ORCID 0000-0002-6077-7490
Kevin Aumiller *Biosphere Sciences and Engineering Division, Carnegie Institution for Science, Baltimore, MD, USA.ORCID 0000-0003-3107-0901
Ren DodgeBiosphere Sciences and Engineering Division, Carnegie Institution for Science, Baltimore, MD, USA.ORCID 0009-0003-9947-7676
Benjamin ObadiaBiosphere Sciences and Engineering Division, Carnegie Institution for Science, Baltimore, MD, USA.ORCID 0000-0002-3286-3236
Ann DengDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.
Sneha AgrawalDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0009-0005-2962-4575
Xincheng YuanDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.
Richard WolffDepartment of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, CA, USA.
Haolong ZhuBiosphere Sciences and Engineering Division, Carnegie Institution for Science, Baltimore, MD, USA.ORCID 0000-0002-9056-0268
Ru-Ching HsiaBiosphere Sciences and Engineering Division, Carnegie Institution for Science, Baltimore, MD, USA.ORCID 0000-0002-8449-089X
Nandita GarudDepartment of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-4217-4407
William B LudingtonBiosphere Sciences and Engineering Division, Carnegie Institution for Science, Baltimore, MD, USA.ORCID 0000-0001-9637-4493

Funding

Evolutionary Dynamics of the Human Gut Microbiome During ColonizationR35GM151023 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Nandita Garud · 2023 to 2026
$1.5M
Host mechanisms of gut colonization by commensal bacteria that affect lifespanR01DK128454 · NIDDK · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI LUDINGTON, WILLIAM BASIL · 2022 to 2024
$1.2M
Serine-rich repeat proteins in evolution of Lactobacillus-host specificityR21AI173779 · NIAID · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI LUDINGTON, WILLIAM BASIL · 2023 to 2024
$452k
NIAID NIH HHS R21 AI173779NIDDK NIH HHS R01 DK128454NIGMS NIH HHS R35 GM151023
6 · The paper itself

Abstract

Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are bacterial cell surface proteins that facilitate attachment to host tissues and are often virulence factors for opportunistic pathogens. However, the attachments are often transient and nonspecific, and additional mechanisms are required to sustain infection. In this work, we use live imaging of individual symbiotic bacterial cells colonizing the gut of living

Indexed as

Adhesins, BacterialDrosophila melanogasterHost SpecificityLactiplantibacillus plantarumAnimalsGenomic IslandsSymbiosisAdhesins, Bacterial

Identifiers

PMID39636981
PMCPMC11914777

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.