ArticlePloS one2024
The mediating role of depression on the link between physical activity and health-related quality of life among people with diabetes: A cross-sectional study.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Effects of depression and suicidal ideation on health-related quality of life in diabetic individuals: findings from a population-based study.Diabetology & metabolic syndrome · 2025Article
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Abstract
introductionA correlation between health-related quality of life (HRQoL) and physical activity has been identified. Many studies have discussed whether this correlation is significantly associated with depression in the general and diabetic populations. However, the role of depression in this relationship, especially in individuals with diabetes, remains incompletely understood.
objectiveThis study investigated the relationship between PA and HRQoL, with depression as a potential mediator, in individuals with diabetes.
methodsThis cross-sectional study involved 1,472 individuals with diabetes who participated in the Korea Health Panel Survey (KHPS) from 2019 to 2020. Their sociodemographic characteristics, PA, depressive symptoms, and HRQoL based on EuroQol-five-dimension (EQ-5D) scores were extracted from the KHPS. The mediating effect of depression on PA and HRQoL was investigated using multiple regression and a mediation effect test.
resultsHRQoL was positively associated with PA, regular exercise, and varying degrees of walking activity. Conversely, depression was substantially negatively associated with HRQoL. Mediation analysis confirmed that depression partially mediated the relationship between PA and HRQoL. Specifically, for PA and regular exercise, the indirect effect of depression accounted for 46.61% (B = 0.002, p < 0.05) and 33.82% (B = 0.003, p < 0.001).
conclusionIn individuals with diabetes, depression was found to mediate the effect of PA on HRQoL. Therefore, conducting depression screening and managing depressive symptoms in this population is crucial to enhancing HRQoL through PA interventions. Consequently, strategies to enhance HRQoL can be effectively implemented and customized in response to particular depression screening outcomes.
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