Evidence map›Paper›PMID 39636765›Full record

ArticleACS sensors2024

Tuning the Localized Microenvironment near a Continuous Glucose Meter to Ensure Monitoring Accuracy and Longevity by Plasma-Induced Grafting Zwitterionic Brushes.

Syuan-Jia Shin, Pei-Chen Lo, Yen-Ting Wu, Huai-Hsaun Shao, Dai-Jin Li, Yung-Cheng Weng, You-Yin Chen, Ta-Chung Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS sensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Syuan-Jia ShinDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, 155 Lin-Ong St., Taipei, Taiwan 11221, ROC.
Pei-Chen LoDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, 155 Lin-Ong St., Taipei, Taiwan 11221, ROC.
Yen-Ting WuDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, 155 Lin-Ong St., Taipei, Taiwan 11221, ROC.
Huai-Hsaun ShaoDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, 155 Lin-Ong St., Taipei, Taiwan 11221, ROC.
Dai-Jin LiDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, 155 Lin-Ong St., Taipei, Taiwan 11221, ROC.
Yung-Cheng WengDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, 155 Lin-Ong St., Taipei, Taiwan 11221, ROC.
You-Yin ChenDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, 155 Lin-Ong St., Taipei, Taiwan 11221, ROC.
Ta-Chung LiuDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, 155 Lin-Ong St., Taipei, Taiwan 11221, ROC.ORCID 0009-0001-9639-909X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is a metabolic disorder that affects millions of individuals worldwide. Continuous glucose monitoring (CGM) offers a prevalent method for continuously monitoring interstitial glucose levels instead of traditional self-monitoring of blood glucose (BG), eliminating the need for finger pricking and providing only discrete data. However, challenges in accuracy persist in CGM, including substantial noise interference and tissue fluid erosion, as well as the pH fluctuations in the localized ISF microenvironment during acute inflammation periods. Herein, we reported a facile atmospheric plasma-induced grafting technique to surface functionalize a zwitterionic brush coating on the sensor, with the aim to adjust the sensor's microenvironmental chemistry. The zwitterionic brush-coated CGM (Z-coated CGM) could regulate pH values with a good glucose response in the pH range from 6.2 to 7.6 and a prolonged sensor life over the uncoated sensor. We evaluated the rat practice that the Z-coated CGM consistently outperformed the uncoated in tracking BG fluctuations, with higher correlation coefficients and significant noise reduction for both non-recalibration and recalibration. This technology holds substantial implications for subcutaneous embedded glucose monitors and facilitates CGMs in achieving independence from routine BG fingerstick calibrations.

Indexed as

Blood GlucoseBlood Glucose Self-MonitoringAnimalsBiosensing TechniquesHydrogen-Ion ConcentrationMalePlasma GasesRatsRats, Sprague-DawleyBlood GlucosePlasma Gasesantifoulingatmospheric plasma-induced graftingcontinuous glucose monitoringmicroenvironmental pHzwitterionic brush

Identifiers

PMID39636765
PMCPMC11686511

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.