Evidence map›Paper›PMID 39636656›Full record

ArticleJournal of the American Chemical Society2024

Biocatalytic Generation of Trifluoromethyl Radicals by Nonheme Iron Enzymes for Enantioselective Alkene Difunctionalization.

James G Zhang, Anthony J Huls, Philip M Palacios, Yisong Guo, Xiongyi Huang

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Examining Pseudohalide (NJournal of inorganic biochemistry · 2026
    Article
  7. Harnessing Photoenzymatic Systems for Intermolecular C-H Fluorination.Angewandte Chemie (International ed. in English) · 2026
    Article
  8. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Enantioconvergent benzylic C(spScience (New York, N.Y.) · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James G ZhangDepartment of Chemistry, Johns Hopkins University; Baltimore, Maryland 21218, United States.ORCID 0000-0002-6802-7061
Anthony J HulsDepartment of Chemistry, Johns Hopkins University; Baltimore, Maryland 21218, United States.
Philip M PalaciosDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.
Yisong GuoDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0002-4132-3565
Xiongyi HuangDepartment of Chemistry, Johns Hopkins University; Baltimore, Maryland 21218, United States.ORCID 0000-0001-7156-8881

Funding

Elucidate Mechanisms of Quinolone Alkaloid Biosynthesis via Iron(II)/2-Oxoglutarate Dependent Enzymes: Diverse, but Controlled ReactivityR01GM125924 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI Yisong Guo · 2018 to 2026
$3.3M
A Chemo-Mimetic Platform to Reprogram Metalloenzymes for Non-Natural Biocatalytic C-H Functionalization ReactionsR35GM147639 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Xiongyi Huang · 2022 to 2026
$2.1M
NIGMS NIH HHS R01 GM125924NIGMS NIH HHS R35 GM147639
6 · The paper itself

Abstract

The trifluoromethyl (-CF

Indexed as

AlkenesBiocatalysisFree RadicalsHydrocarbons, FluorinatedMolecular StructureNonheme Iron ProteinsStereoisomerismAlkenesFree RadicalsHydrocarbons, FluorinatedNonheme Iron Proteins

Identifiers

PMID39636656
PMCPMC12202083

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.