Can a Hybrid Line Break a Selection Limit on Behavioral Evolution in Mice?

Layla Hiramatsu, Vincent Careau, Theodore Garland

Abstract read

In one paragraph

Article in Behavior genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Layla HiramatsuDepartment of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA, USA.ORCID 0000-0001-6298-6109

Vincent CareauDepartment of Biology, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-2826-7837

Theodore GarlandDepartment of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA, USA. tgarland@ucr.edu.ORCID 0000-0002-7916-3552

Funding

Directorate for Biological Sciences IOS-1121273, DEB-1655362, IOS-2038528

6 · The paper itself

Abstract

Artificial selection yielded four replicate high runner (HR) lines of mice that reached apparent selection limits (~ threefold increase in wheel revolutions per day vs. four control lines), despite maintenance of additive genetic variance. After 68 generations, we used animal models to test for changes in additive-genetic variances and covariance of the two measured components (average speed and duration) of running distance. We also attempted to break the selection limit by crossing two HR lines, then continuing directional selection on this hybrid line and on the two parental lines for nine generations. The genetic correlation between speed and duration was positive in the base population, but evolved to be negative in the two parental HR lines. Although heritability for both speed and duration (but not distance) increased in the hybrid line, their genetic correlation remained negative. Hybrid F

Indexed as

Behavior, AnimalBiological EvolutionHybridization, GeneticSelection, GeneticAnimalsFemaleGenetic VariationHybrid VigorMaleMiceRunningArtificial selectionGenetic architectureHeterosisHybridVoluntary exerciseWheel running

Identifiers

PMID39636486

DOI10.1007/s10519-024-10209-7

PMCPMC11790750

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.