Observational studyEuropean radiology experimental2024
Focal liver lesions: multiparametric microvasculature characterization via super-resolution ultrasound imaging.
Observational study in European radiology experimental, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06018142 (Clinical Application of Super-resolution Ultrasound), which is not on this map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Application of Super-resolution Ultrasound(SR-US) Imaging in Solid Tumors
Who cites it
7 citing papers in PubMed.
- Interpretable prediction of macrotrabecular-massive HCC and recurrence-free survival by integrating MRI LI-RADS features with deep learning habitat radiomics.European radiology experimental · 2026Observational
- Super-resolution ultrasound microscopy profiles microvasculomics of pancreatic ductal adenocarcinoma with pathological association and facilitates differential diagnosis.La Radiologia medica · 2026Article
- [Ultrasound technology's new application in the diagnosis and treatment of liver cancer].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
- Super-resolution contrast-enhanced ultrasound: recent advances.Ultrasonography (Seoul, Korea) · 2026Article
- A Case of Misdiagnosed Hepatic Sarcoidosis: Evaluating Ultrasound Resolution Microscopy for Differentiating Hepatic Sarcoidosis from Hepatocellular Carcinoma.Diagnostics (Basel, Switzerland) · 2026Article
- A reproducible ultrasound localization microscopy framework for the quantitative imaging of hepatocellular carcinoma on a clinical ultrasound system.Theranostics · 2026Article
- Lower diffusion-derived vessel density (DDVD) measure of liver focal nodular hyperplasia than those of hepatocellular carcinoma and liver metastasis allows potential differential diagnosis: quantitative and semi-quantitative analyses of two-center data.Journal of gastrointestinal oncology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundNoninvasive and functional imaging of the focal liver lesion (FLL) vasculature at microscopic scales is clinically challenging. We investigated the feasibility of using super-resolution ultrasound (SR-US) imaging for visualizing and quantifying the microvasculature of intraparenchymal FLLs.
methodsPatients with FLLs between June 2022 and February 2023 were prospectively screened. Following bolus injection of microbubbles at clinical concentration, SR-US was performed using a high frame rate (350-500 Hz) modified ultrasound scanner and a convex array transducer with a central frequency of 3.1 MHz.
resultsIn total, 47 pathologically proven FLLs at a depth of 5.7 ± 1.7 cm (mean ± standard deviation) were included: 30 hepatocellular carcinomas (HCC), 11 liver metastases (LM), and 6 focal nodular hyperplasias (FNH). The smallest detectable vessel size of the hepatic microvasculature was 128.4 ± 18.6 μm (mean ± standard deviation) at a depth of 8 cm. Significant differences were observed among the three types of lesions in terms of pattern categories, vessel density, minimum flow velocity, and perfusion index. We observed higher vessel density for FNH versus liver parenchyma (p < 0.001) as well as fractal dimension and local flow direction entropy value for FNH versus HCC (p = 0.002 and p < 0.001, respectively) and for FNH versus LM (p = 0.006 and p = 0.002, respectively).
conclusionMultiparametric SR-US showed that these three pathological types of FLLs have specific microvascular phenotypes. Vessel density, fractal dimension and local flow direction entropy served as valuable parameters in distinguishing between benign and malignant FLLs.
trial registrationClinicalTrials.gov (NCT06018142). RELEVANCE STATEMENT: Multiparametric SR-US imaging offers precise morphological and functional assessment of the microvasculature of intraparenchymal focal liver lesions, providing insights into tumor heterogeneity and angiogenesis. KEY POINTS: Super-resolution (SR)-US imaging allowed morphological and functional evaluation of intraparenchymal hepatic lesion microvasculature. Hepatocellular carcinoma, liver metastasis, and focal nodular hyperplasia exhibit distinct microvascular architectures and hemodynamic profiles. Multiparametric microvasculature characterization via SR-US imaging facilitates the differentiation between benign and malignant microvascular phenotypes.
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