Evidence map›Paper›PMID 39636309›Full record

ArticleClinical neuroradiology2025

Decreased Cortical Sulcus Depth in Parkinson's Disease with Excessive Daytime Sleepiness.

Lina Wang, Chi Zhang, Bijia Wang, Li Zhang, Guangjun Xi, Jingyu Deng, Feng Wang

Abstract read
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In one paragraph

Article in Clinical neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lina WangDepartment of Neurology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, No.299 Qingyang Road, 214023, Wuxi, China. linawang0363@126.com.
Chi ZhangSchool of Communications and Information Engineering, Nanjing University of Posts and Telecommunications, Nanjing, China.
Bijia WangDepartment of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Li ZhangDepartment of Neurology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, No.299 Qingyang Road, 214023, Wuxi, China.
Guangjun XiDepartment of Neurology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, No.299 Qingyang Road, 214023, Wuxi, China.
Jingyu DengDepartment of Neurology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, No.299 Qingyang Road, 214023, Wuxi, China.
Feng WangDepartment of Neurology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, No.299 Qingyang Road, 214023, Wuxi, China. wangfeng_njmu@163.com.

Funding

Jiangsu Provincial Basic Research Program Natural Science Foundation Youth Fund Project No. BK20240307Wuxi Municipal Health Commission No. Q202344Wuxi People's Hospital Doctor Talent Foundation No. BSRC202307
6 · The paper itself

Abstract

introductionExcessive daytime sleepiness (EDS), a prevalent non-motor symptom in Parkinson's disease (PD), significantly impacts the quality of life for PD patients and elevates the risks of injury. Our study is to investigate the altered cortical surface morphology characteristics in PD patients with EDS (PD-EDS).

methodsClinical data and magnetic resonance imaging were obtained from the Parkinson's Progression Marker Initiative database, comprising 36 PD-EDS and 98 PD patients without EDS (PD-nEDS). The computational anatomy toolbox was utilized to derive sulcus depth (SD) and deep grey matter (GM) nuclei volumes.

resultsPD-EDS patients exhibited significantly decreased SD values in the right caudal middle frontal gyrus, pars opercularis, and superior temporal cortex relative to PD-nEDS patients. However, no significant differences in deep GM nuclei volumes were identified. Receiver operating characteristic (ROC) curve analyses further revealed that these cortical SD values could potentially serve as a screening index for distinguishing PD-EDS from PD-nEDS. Additionally, although PD-EDS patients had a longer disease duration and poorer performance in motor function and depression compared to PD-nEDS patients, these factors were included as covariates in the neuroimaging analyses.

conclusionOur study findings demonstrated that decreased cortical SD values might induce sleep-wake state instability and contribute to the pathophysiological mechanisms of EDS in early-stage PD.

Indexed as

Cerebral CortexDisorders of Excessive SomnolenceMagnetic Resonance ImagingParkinson DiseaseAgedFemaleHumansMaleMiddle AgedCerebral cortexExcessive daytime sleepinessMagnetic resonance imagingParkinson’s diseaseSulcus depth

Identifiers

PMID39636309

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.