Evidence map›Paper›PMID 39636212›Full record

ArticleeLife2024

Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus.

Jasmine Rowell, Ching-In Lau, Susan Ross, Diana C Yanez, Oscar A Peña, Benny Chain, Tessa Crompton

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jasmine RowellUCL Great Ormond Street Institute of Child Health, London, United Kingdom.ORCID https://orcid.org/0000-0001-7040-8528
Ching-In LauUCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Susan RossUCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Diana C YanezUCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Oscar A PeñaSchool of Biochemistry, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-2582-0238
Benny ChainDivision of Infection and Immunity, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-7417-3970
Tessa CromptonUCL Great Ormond Street Institute of Child Health, London, United Kingdom.ORCID https://orcid.org/0000-0002-8973-4021

Funding

Biotechnology and Biological Sciences Research Council 1903458Biotechnology and Biological Sciences Research Council BB/T020970/1Medical Research Council MR/P000843/1Medical Research Council MR/S037764/1
6 · The paper itself

Abstract

Here, we sequenced rearranged TCRβ and TCRα chain sequences in CD4

Indexed as

FetusMajor Histocompatibility ComplexReceptors, Antigen, T-CellThymus GlandAnimalsComplementarity Determining RegionsFemaleGenes, T-Cell Receptor alphaGenes, T-Cell Receptor betaHydrocortisoneMaleMice, Inbred C57BLPregnancyPrincipal Component AnalysisThymocytesComplementarity Determining RegionsHydrocortisoneReceptors, Antigen, T-CellimmunologyinflammationMHC-restrictionmouserepertoire selectionT-cell developmentTCR repertoireTCR sequencingthymus

Identifiers

PMID39636212
PMCPMC11620746

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.