Evidence map›Paper›PMID 39636205›Full record

ArticleJournal of cellular and molecular medicine2024

Integrative Genomic and Transcriptomic Analysis in Acute Interstitial Pneumonia.

Donghee Kwak, Junho Kang, Yeuni Yu, Hansong Lee, Yeongjoo Kim, Eun Jung Kwon, Dong Min Lim, Seongik Mun, Hyo Min Kim, Hae Seul Lee and 3 more

Abstract read
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In one paragraph

Article in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Donghee KwakConvergence Medical Sciences, Pusan National University, Yangsan, Republic of Korea.
Junho KangDepartment of Research, Keimyung University Dongsan Medical Center, Daegu, Republic of Korea.
Yeuni YuMedical Research Institute, Pusan National University, Yangsan, Republic of Korea.
Hansong LeeMedical Research Institute, Pusan National University, Yangsan, Republic of Korea.
Yeongjoo KimInterdisciplinary Program of Genomic Data Science, Pusan National University, Yangsan, Republic of Korea.
Eun Jung KwonInterdisciplinary Program of Genomic Data Science, Pusan National University, Yangsan, Republic of Korea.
Dong Min LimInterdisciplinary Program of Genomic Data Science, Pusan National University, Yangsan, Republic of Korea.
Seongik MunInterdisciplinary Program of Genomic Data Science, Pusan National University, Yangsan, Republic of Korea.
Hyo Min KimInterdisciplinary Program of Genomic Data Science, Pusan National University, Yangsan, Republic of Korea.
Hae Seul LeeConvergence Medical Sciences, Pusan National University, Yangsan, Republic of Korea.
Yun Hak KimDepartment of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea.ORCID 0000-0002-9796-8266
Hye Ju YeoDepartment of Internal Medicine, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
Woo Hyun ChoDepartment of Internal Medicine, School of Medicine, Pusan National University, Yangsan, Republic of Korea.

Funding

Korea Research Environment Open NetworkMinistry of Science and ICT, South Korea RS-2024-00439078
6 · The paper itself

Abstract

Acute Interstitial Pneumonia (AIP) represents a severe form of diffuse lung injury within the idiopathic interstitial pneumonia spectrum. Given the limited understanding of its molecular basis, this study aims to elucidate AIP's genomic and transcriptomic profiles to uncover its pathophysiological underpinnings and identify potential therapeutic targets. We conducted a comprehensive analysis of genomic and transcriptomic data from lung tissues of 15 AIP patients. This included assessing differentially expressed genes (DEGs) and identifying mutations in exonic coding variants, as well as analysing expression quantitative trait loci (eQTL) profiles to link non-coding SNP genotypes with gene expression levels. Transcriptomic analysis revealed a significant upregulation of genes linked to the Type I interferon receptor and keratin filament, and a downregulation of genes related to focal adhesion and endothelial integrity, compared to healthy individuals. These patterns were distinct from those observed in idiopathic pulmonary fibrosis (IPF) and non-IPF interstitial lung diseases (ILDs). Genomic analysis highlighted mutations in genes associated with keratin and the extracellular matrix. Additionally, eQTL profiling provided insights into the genetic regulation of gene expression in AIP. Our findings reveals AIP's unique molecular landscape, differentiating it from other ILDs and laying the groundwork for future diagnostic and therapeutic research.

Indexed as

Gene Expression ProfilingGenomicsLung Diseases, InterstitialQuantitative Trait LociTranscriptomeAcute DiseaseAgedFemaleGene Expression RegulationHumansLungMaleMiddle AgedMutationPolymorphism, Single Nucleotideacute interstitial pneumoniaexpression quantitative trait locitranscriptomicswhole genome sequencing

Identifiers

PMID39636205
PMCPMC11619155

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.