Evidence map›Paper›PMID 39636126›Full record

Observational studyAntimicrobial agents and chemotherapy2025

Antibacterial and antifungal drug concentrations in intra-abdominal abscesses: a prospective clinical study.

Alicia Cancela Costa, Fabian Grass, Ignacio Andres Cano, Florian Desgranges, Constant Delabays, Antonios Kritikos, Emmanouil Glampedakis, Thierry Buclin, Rafael Duran, Benoit Guery and 4 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Clinical Significance ofMicroorganisms · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alicia Cancela CostaService of Infectious Diseases, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Fabian GrassDepartment of Visceral Surgery, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Ignacio Andres CanoDepartment of Radiology and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Florian DesgrangesService of Infectious Diseases, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Constant DelabaysDepartment of Visceral Surgery, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Antonios KritikosService of Infectious Diseases, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Emmanouil GlampedakisService of Infectious Diseases, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Thierry BuclinService and Laboratory of Clinical Pharmacology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Rafael DuranDepartment of Radiology and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Benoit GueryService of Infectious Diseases, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-6526-0714
Jean-Luc PaganiAdult Intensive Care Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Emilie UldryDepartment of Visceral Surgery, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Laurent Arthur DecosterdService and Laboratory of Clinical Pharmacology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-9840-1325
Frederic LamothService of Infectious Diseases, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-1023-5597

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secondary peritonitis with intra-abdominal abscesses (IAA) is difficult to treat because of the supposed low rate of penetration of antimicrobial drugs at the site of infection. However, clinical data about the actual bioavailability of antimicrobial drugs in IAA are scarce. This prospective observational study aimed at assessing the drug penetration in IAA of the antibiotics (piperacillin-tazobactam, carbapenems) and antifungals (fluconazole, echinocandins) that are usually recommended for the treatment of intra-abdominal infections. Patients with IAA who underwent a radiological or surgical drainage procedure were included. Antimicrobial drug concentrations were measured in IAA (C

Indexed as

Abdominal AbscessAnti-Bacterial AgentsAntifungal AgentsAdultAgedbeta-LactamsCarbapenemsErtapenemFemaleFluconazoleHumansImipenemMaleMeropenemMicrobial Sensitivity TestsMiddle AgedAnti-Bacterial AgentsAntifungal Agentsbeta-LactamsCarbapenemsErtapenemFluconazoleImipenemMeropenemPenicillanic AcidPiperacillinPiperacillin, Tazobactam Drug Combinationanidulafunginbioavailabilitycaspofunginertapenemfluconazoleimipenemmeropenemperitonitispiperacillinsurgical

Identifiers

PMID39636126
PMCPMC11784227

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.