Evidence map›Paper›PMID 39636029›Full record

ArticleClimacteric : the journal of the International Menopause Society2025

Concentration and genetic regulation of sex hormone binding globulin and fracture risk in older women.

Yuanyuan Wang, Chenglong Yu, Rakibul M Islam, Sultana Monira Hussain, Anna L Barker, Paul Lacaze, John J McNeil, Susan R Davis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Climacteric : the journal of the International Menopause Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuanyuan WangSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-7629-4178
Chenglong YuSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Rakibul M IslamSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-0889-8658
Sultana Monira HussainSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Anna L BarkerSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Paul LacazeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
John J McNeilSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Susan R DavisSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI CHAN, ANDREW T, MCNEIL, JOHN JAMES · 2019 to 2023
$42.9M
NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682
6 · The paper itself

Abstract

objectiveThis study aimed to examine the association between concentrations of sex hormone binding globulin (SHBG) and fracture risk in community-dwelling older women and explore whether this was explained by the genetic regulation of SHBG.

methodsThis prospective cohort study examined 4871 women aged ≥70 years who were not taking medications influencing SHBG concentrations. A genome-wide association study was undertaken to identify single nucleotide polymorphisms (SNPs) associated with SHBG concentrations. Incident fracture was confirmed by medical imaging and adjudicated by expert review committee.

resultsThe median age of participants was 74.0 years. Over 3.9 (standard deviation 1.4) years of follow-up, 484 participants had an incident fracture. There was a linear trend for a positive association between SHBG concentrations and fracture risk (

conclusionSHBG concentrations were positively associated with a greater fracture risk in community-dwelling women aged ≥70 years, which was not explained by genetic variants associated with SHBG regulation.

Indexed as

Fractures, BoneSex Hormone-Binding GlobulinAgedAged, 80 and overFemaleGenome-Wide Association StudyHumansPolymorphism, Single NucleotideProspective StudiesRisk FactorsSex Hormone-Binding Globulinfracturegenome-wide association studyolder womenSex hormone binding globulin

Identifiers

PMID39636029
PMCPMC11949721

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.