Evidence map›Paper›PMID 39635317›Full record

ArticleWorld journal of radiology2024

Right-to-left shunt detection

Man-Juan Yao, Ying-Ying Zhao, Shui-Ping Deng, Hua-Hua Xiong, Jing Wang, Li-Jie Ren, Li-Ming Cao

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Article in World journal of radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Man-Juan YaoDepartment of Neurology, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, Guangdong Province, China.
Ying-Ying ZhaoDepartment of Ultrasound, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, Guangdong Province, China.
Shui-Ping DengDepartment of Ultrasound, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, Guangdong Province, China.
Hua-Hua XiongDepartment of Ultrasound, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, Guangdong Province, China.
Jing WangDepartment of Ultrasound, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, Guangdong Province, China.
Li-Jie RenDepartment of Neurology, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, Guangdong Province, China.
Li-Ming CaoDepartment of Neurology, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, Guangdong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatent foramen ovale (PFO)-related right-to-left shunts (RLSs) have been implicated in cryptogenic stroke and migraine, with larger shunts posing a higher risk. When used individually to detect RLS, contrast transcranial Doppler (cTCD) and contrast transthoracic echocardiography (cTTE) may yield false-negative results. Further, the literature exposes gaps regarding the understanding of the limitations of cTCD and cTTE, presents conflicting recommendations on their exclusive use, and highlights inefficiencies associated with nonsynchronous testing.

aimTo investigate the accuracy of multimodal ultrasound to improve diagnostic efficiency in detecting PFO-related RLSs.

methodsWe prospectively enrolled four patients with cryptogenic stroke (

resultscTTE identified moderate and large RLSs in patients with recurrent cryptogenic stroke and migraines, whereas cTCD revealed only small RLSs. Moderate and large RLS were confirmed on combined cTTE and cTCD. After excluding other causes, both patients underwent PFO occlusion. At 21- and 24-month follow-up examinations, neither stroke nor migraine had recurred. cTTE revealed a small RLS in a third patient with unexplained dizziness and a fourth patient with migraines; however, simultaneous cTCD detected a large RLS. These patients did not undergo interventional occlusion, and dizziness and headache recurred at the 17- and 24-month follow-up examinations.

conclusionUsing cTTE or cTCD may underestimate RLS, impairing risk assessments. Combining synchronized cTCD with cTTE could enhance testing accuracy and support better diagnostic and therapeutic decisions.

Indexed as

Contrast transcranial DopplerContrast transthoracic echocardiographyCryptogenic strokeMultimodal ultrasonographyPatent foramen ovaleRight-to-left shunt

Identifiers

PMID39635317
PMCPMC11612799

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.