Evidence map›Paper›PMID 39635266›Full record

ArticleFrontiers in cardiovascular medicine2024

Association of cumulative non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with the risk of cardiometabolic disease.

Luqing Liu, Shihe Liu, Yicheng Liao, Xiaoxue Zhang, Meixiao Wang, Liming Lin, Chenrui Zhu, Shouling Wu, Yuntao Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luqing LiuDepartment of Cardiology, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, China.
Shihe LiuDepartment of Cardiology, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, China.
Yicheng LiaoDepartment of Cardiology, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, China.
Xiaoxue ZhangDepartment of Cardiology, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, China.
Meixiao WangDepartment of Cardiology, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, China.
Liming LinDepartment of Cardiology, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, China.
Chenrui ZhuDepartment of Cardiology, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, China.
Shouling WuDepartment of Cardiology, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, China.
Yuntao WuDepartment of Cardiology, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: One measurement of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is considered to be associated with insulin resistance and cardiovascular disease (CVD) risk. This study aimed to exploring the association between cumulative non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol (Cum NHHR) exposure levels and the risk of cardiometabolic disease (CMD). Methods: This prospective cohort study included 43,735 participants, who participated in three consecutive health examinations in 2006, 2008, 2010 and had no history of CMD or cancer. The participants were divided into quartiles bases on their cum NHHR. Multivariate Cox proportional hazards model was used to assess the association between cum NHHR and the risk of CMD. Additionally, the direct method of standardized ratios was employed to calculate the absolute risk of CMD attributable to cum NHHR. Results: Over a median follow-up period of 10.92 years (IQR: 10.22-11.26 years), 7,388 participants were newly diagnosed with CMD. In the multivariate-adjusted model, participants in quartiles Q2, Q3 and Q4 showed a progressively increased relative risk of CMD compared to those in Q1, The fully adjusted hazard ratios (95% confidence intervals) for the risk of CMD in the Q2, Q3, and Q4 groups were 1.11 (1.04-1.20), 1.23 (1.14-1.32), and 1.29 (1.20-1.38), respectively, compared with the Q1 group. This association remained significant even after further adjustment for single measurements of NHHR. Moreover, cum NHHR was positively correlated with the absolute risk of CMD, cardiovascular diseases (CVD), and type 2 diabetes (T2DM). Conclusions: Higher cum NHHR is significantly associated with an increased risk of CMD, independent of single-point NHHR level. Additionally, there are significant different strengths of correlations between cum NHHR and different diseases.

Indexed as

cardiometabolic diseasecumulative exposureepidemiologyinfluencing factorsnon-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio

Identifiers

PMID39635266
PMCPMC11614763

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.