Evidence map›Paper›PMID 39634265›Full record

ArticleFrontiers in oncology2024

Case report: Tracing in parallel the salivary and gut microbiota profiles to assist Larotrectinib anticancer treatment for

Luigia Turco, Rosa Della Monica, Pasqualina Giordano, Mariella Cuomo, Manuele Biazzo, Baptiste Mateu, Raimondo Di Liello, Bruno Daniele, Nicola Normanno, Antonella De Luca and 7 more

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Luigia TurcoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Rosa Della MonicaCEINGE-Advanced Biotechnologies "Franco Salvatore", Naples, Italy.
Pasqualina GiordanoUOC Oncologia Ospedale del Mare, ASL Napoli 1 Centro, Naples, Italy.
Mariella CuomoCEINGE-Advanced Biotechnologies "Franco Salvatore", Naples, Italy.
Manuele BiazzoThe BioArte, San Gwann, Malta.
Baptiste MateuDepartment of Pharmacy, University of Naples "Federico II", Naples, Italy.
Raimondo Di LielloUOC Oncologia Ospedale del Mare, ASL Napoli 1 Centro, Naples, Italy.
Bruno DanieleUOC Oncologia Ospedale del Mare, ASL Napoli 1 Centro, Naples, Italy.
Nicola NormannoScientific Directorate, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Antonella De LucaCell Biology and Biotherapy Unit, Istituto Nazionale Tumori - IRCCS Fondazione G. Pascale, Naples, Italy.
Anna Maria RachiglioCell Biology and Biotherapy Unit, Istituto Nazionale Tumori - IRCCS Fondazione G. Pascale, Naples, Italy.
Carmela ChiaramonteUOC Neurochirurgia Ospedale del Mare, ASL Napoli 1 Centro, Naples, Italy.
Francesca Maria GiuglianoUOC Radioterapia Ospedale del Mare, ASL Napoli 1 Centro, Naples, Italy.
Lorenzo ChiariottiCEINGE-Advanced Biotechnologies "Franco Salvatore", Naples, Italy.
Giuseppe CatapanoUOC Neurochirurgia Ospedale del Mare, ASL Napoli 1 Centro, Naples, Italy.
Lorena CorettiDepartment of Pharmacy, University of Naples "Federico II", Naples, Italy.
Francesca LemboDepartment of Pharmacy, University of Naples "Federico II", Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oncotherapy can shape intestinal microbiota, which, in turn, may influence therapy effectiveness. Furthermore, microbiome signatures during treatments can be leveraged for the development of personalised therapeutic protocols in cancer treatment based on the identification of microbiota profiles as prognostic tools. Here, for the first time, the trajectory of gut and salivary microbiota in a patient treated with Larotrectinib, a targeted therapy approved for diagnosed glioblastoma multiforme neurotrophic tyrosine receptor kinase (

Indexed as

full-length 16S rRNA gene sequencingglioblastoma multiformeNTRK-gene fusiononcotherapysaliva and feces microbiota profiles

Identifiers

PMID39634265
PMCPMC11614819

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.