Evidence map›Paper›PMID 39634185›Full record

ArticleFrontiers in endocrinology2024

18F-AlF-NOTA-octreotide PET/CT and 3D printing technology for precision diagnosis and treatment of phosphaturic mesenchymal tumors in patients with tumor-induced osteomalacia: two case reports.

Gang Zhao, Lijuan Guan, Yongqiang Zhang, Xingzhen Shi, Wenming Luo, Maiqing Yang, Qi Wang, Zhen Liu, Yongqiang Liu, Xiaolei Ding and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Gang ZhaoDepartment of Orthopedics and Trauma, Weifang People's Hospital, First Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Lijuan GuanNursing Department, Weifang Stomatology Hospital, Weifang, China.
Yongqiang ZhangDepartment of Orthopedics and Trauma, Weifang People's Hospital, First Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Xingzhen ShiDepartment of Orthopedics and Trauma, Weifang People's Hospital, First Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Wenming LuoDepartment of Orthopedics and Trauma, Weifang People's Hospital, First Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Maiqing YangDepartment of Pathology, Weifang People's Hospital, First Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Qi WangDepartment of Orthopedics and Trauma, Weifang People's Hospital, First Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Zhen LiuDepartment of Orthopedics and Trauma, Weifang People's Hospital, First Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Yongqiang LiuDepartment of Orthopedics and Trauma, Weifang People's Hospital, First Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Xiaolei DingCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Jie ZhaoDepartment of Orthopedics and Trauma, Weifang People's Hospital, First Affiliated Hospital of Shandong Second Medical University, Weifang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aims to report the application of 18F-AlF-NOTA-Octreotide PET/CT and 3D printing technology in the diagnosis and treatment of phosphaturic mesenchymal tumors (PMT) in patients with tumor-induced osteomalacia (TIO). Case presentation: A 68-year-old male patient (Case 1) was admitted to the Weifang People's Hospital in August 2022 with complaints of "persistent pain in the bilateral flank and lumbosacral region". 18F-AlF-NOTA-Octreotide PET/CT showed high octreotide expression in the left femoral region. A 48-year-old male patient (Case 2) was admitted to the Weifang People's Hospital in November 2022, complaining of "pain in the lumbar region and ribs". 18F-AlF-NOTA-Octreotide PET/CT showed high octreotide expression in the pancreatic uncinate process and the left acetabulum. They were diagnosed with hypophosphatemic osteomalacia, with a strong consideration of an underlying neuroendocrine tumor. Preoperative design of 3D virtual surgery, CAD/CAM, and 3D printing technology were used to customize the digital surgical guide plates, and the surgery was carried out. They were both finally confirmed as phosphateuric mesenchymal tumors (PMT) based on postoperative pathology and immunohistochemistry results. Both patients experienced substantial relief from their clinical manifestations after surgery. Conclusion: 18F-AlF-NOTA-Octreotide PET/CT may be a precise diagnostic method for TIO, while 3D printing technology may serve as an effective and dependable adjunct for the treatment of PMT in patients with TIO.

Indexed as

Neoplasms, Connective TissueOctreotideOsteomalaciaPositron Emission Tomography Computed TomographyPrinting, Three-DimensionalAgedFluorine RadioisotopesHeterocyclic CompoundsHeterocyclic Compounds, 1-RingHumansMaleMiddle AgedParaneoplastic SyndromesPrecision MedicineRadiopharmaceuticals1,4,7-triazacyclononane-N,N',N''-triacetic acidFluorine RadioisotopesHeterocyclic CompoundsHeterocyclic Compounds, 1-RingOctreotideRadiopharmaceuticals18F-AlF-NOTA-octreotide PET/CT imaging3D printing technologycase reportsphosphaturic mesenchymal tumorstumor-induced osteomalacia

Identifiers

PMID39634185
PMCPMC11614613

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.