ArticleFrontiers in plant science2024
Engineering rice Nramp5 modifies cadmium and manganese uptake selectivity using yeast assay system.
Article in Frontiers in plant science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Molecular insights into cadmium transport and micronutrient crosstalk in rice: Towards minimizing grain Cd.Journal of integrative plant biology · 2026Review
- Genome-wide identification of NRAMP gene family in Brassica U's triangle species and its response to Cadmium stress in B. napus.BMC plant biology · 2026Article
- Molecular Evolution and Mechanisms of Plants NRAMP Transporters in Response to Heavy Metal Stress.Plants (Basel, Switzerland) · 2026Review
- Pyramiding elite alleles of the genetically linked OsNRAMP5 and OsHMA3 confers low Cd accumulation in rice grains without compromising stress tolerance.Plant communications · 2026Article
- Article
- Genome-wide identification of the NRAMP gene family in wheat and its ancestral species, and preliminary functional study ofFrontiers in plant science · 2026Article
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Authors and funding
4 authors.
Funding
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Abstract
Cd is a seriously hazardous heavy metal for both plants and humans and international regulations regarding Cd intake have become stricter in recent years. Three-quarters of the Cd intake comes from plant-based foods, half of which comes from cereals. Therefore, it is anticipated that the Cd uptake efficiency of cereals, including rice, a staple crop in Asia, will be reduced. Natural resistance-associated macrophage protein (Nramp) is the principal transporter involved in the uptake and translocation of metal ions in various plants. In rice, OsNramp5 is a transporter of Mn, which is an essential micronutrient for plant growth, and is responsible for Cd uptake. Although several attempts have been made to engineer the metal uptake characteristics of OsNramp5, in many cases, both Cd and Mn uptake efficiencies are impaired. Therefore, in this study, we engineered OsNramp5 to reduce Cd uptake while retaining Mn uptake efficiency for low-Cd rice production. OsNramp5 was engineered using amino acid substitution(s) at the 232
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