ArticleHealth promotion perspectives2024
Effects of propolis supplementation on prooxidant-antioxidant balance, oxidative stress biomarkers, and body composition in obese patients with NAFLD: A double-blind randomized controlled clinical trial.
Article in Health promotion perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Brazilian Green Propolis and Essential Oil Residues Improve Metabolic Dysfunction by Modulating Key Hepatic Lipogenic Genes in High-Fat Diet-Fed Mice.Journal of food science · 2026Article
- Propolis in Obesity and Related Metabolic Disorders: Mechanistic and Clinical Insights-A Scoping Review.Nutrients · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oxidative stress is one of the main hits in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Propolis (PRP), a natural substance made by bees from plant extracts, has been reported to have antioxidant properties. The present clinical trial investigated the effect of Iranian PRP on prooxidant-antioxidant balance (PAB), oxidative stress biomarkers, and body composition in obese patients with NAFLD. Methods: In the present double-blind, randomized controlled clinical trial, 44 obese patients with NAFLD were randomly allocated to either Iranian PRP (1500 mg/d) or placebo (1500 mg/d) accompanied by a calorie-restricted diet (CRD) for eight weeks. PAB, oxidative stress biomarkers, and body composition were assessed at baseline and the end of the study. Results: There was a significant reduction in PAB levels over the trial in both groups. However, the between-group difference was not significant at the endpoint. At the end of the study, the inter-group comparison showed a significant decrease in serum glutathione peroxidase level in the placebo group compared to the PRP group after adjusting for confounding variables based on models 1 ( Conclusion: Iranian PRP supplementation (1500 mg/d) for eight weeks could prevent the reduction of glutathione peroxidase levels compared to the control group. However, it could not affect other oxidative stress biomarkers, body composition, or dietary intakes of energy and antioxidant micronutrients.
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