ReviewMolecular neurodegeneration2024
Aging-associated sensory decline and Alzheimer's disease.
Review in Molecular neurodegeneration, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The correlation between olfactory bulb volume and T&T odor threshold: a systematic review and meta-analysis.Brain imaging and behavior · 2026Pooled it
- Dapagliflozin restores odour-induced functional integration of primary olfactory cortex circuit but not olfactory-related regional brain activation in patients with type 2 diabetes: A 16-week randomised comparative study.Diabetes, obesity & metabolism · 2025Trial
- Novel cell markers with altered expression in brain aging and Alzheimer's disease: A review.IBRO neuroscience reports · 2026Article
- Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Potential Indicators of Transition to Cognitive Decline in Older Men: A Longitudinal Analysis of Multiple Sensory, Balance, and Gait Changes.Diagnostics (Basel, Switzerland) · 2026Article
- Brain-wide fMRI responses to auditory and visual stimuli in awake mice.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Dementia Risk After Glaucoma Surgery and Medical Therapy: A Multicentre Real-World Cohort Study.International journal of geriatric psychiatry · 2026Article
- Review
- Assessing the Mediating Roles of Global Sensory Impairment, Social Isolation, and Loneliness in the Association Between Education and Cognitive Function.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Genetic evidence for a causal role of depression in late-onset Alzheimer disease: A Mendelian randomization study.Medicine · 2026Article
- Sensory decline in aging and neurodegeneration: A mitochondrial perspective.Pharmacological research · 2026Review
- Sensory impairment, epigenetic ageing, and later-life functional decline and mortality in older adults.GeroScience · 2026Article
- Exploring the Relationship Between Hearing Loss and Cognitive Dysfunction from the Perspective of Molecular Mechanisms.Biomolecules · 2026Review
- Color-modulated olfactory testing using RAPPIT: An innovative tool for early detection of cognitive decline.Journal of Alzheimer's disease : JAD · 2026Article
- Auditory Biomarkers in Neurodegenerative Disorders: A Literature Review.Journal of otology · 2026Review
- Hearing Loss, Cognitive Decline, and Dementia: Clinical Intersections.Audiology research · 2026Review
- Reliability, repeatability, and age associations of the dogSIT (dog Smell Interaction Test) battery in untrained companion dogs (Canis lupus familiaris).Scientific reports · 2026Article
- Alzheimer's disease and cerebrovascular biomarkers in relation to odor identification in a naturalistic clinical cohort.Alzheimer's research & therapy · 2026Article
- Mind-Body Interventions as Modulators of Neural Connectivity and Cognition in Individuals at Risk for Alzheimer's Disease: A Systematic Review.Annals of neurosciences · 2026Review
- Physical function impacts hearing without mediation from systolic blood pressure.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Multisensory decline is common as people age, and aging is the primary risk of Alzheimer's Disease (AD). Recent studies have begun to shed light on the possibility that age-related sensory decline could accelerate AD pathogenesis, or be a prodromal indicator of AD. Sensory impairments, specifically in taste and smell, often emerge before cognitive symptoms in AD, indicating their potential as early biomarkers. Olfactory dysfunction has been frequently associated with AD and may offer valuable insights into early detection. Hearing impairment is significantly associated with AD, but its causal impact on AD progression remains unclear. The review also discusses visual and tactile deficits in AD, including retinal thinning and changes in tactile perception, highlighting their links to disease progression. Focusing on molecular mechanisms, the review explores the roles of amyloid-β (Aβ) accumulation and tau protein pathology in sensory decline and their bidirectional relationship with AD. In summary, the evidence presented conclusively supports advocating for an integrated approach to understanding AD and sensory decline, to enhance early detection, implementing preventive strategies, and developing therapeutic interventions for AD. This approach underscores the significance of sensory health in addressing neurodegenerative diseases, particularly AD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.