Evidence map›Paper›PMID 39633206›Full record

ArticleCardiovascular engineering and technology2025

Assessing the Impact of Cardiac Output and Valve Orientation on Bioprosthetic Pulmonary Valve Hemodynamics Using In Vitro 4D-Flow MRI and High-Speed Imaging.

Nicole K Schiavone, Priya J Nair, Christopher J Elkins, Doff B McElhinney, Daniel B Ennis, John K Eaton, Alison L Marsden

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Article in Cardiovascular engineering and technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Nicole K Schiavone *Department of Mechanical Engineering, Stanford University, Stanford, CA, USA.
Priya J Nair *Department of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6326-9777
Christopher J ElkinsDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA.
Doff B McElhinneyDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Daniel B EnnisDepartment of Radiology, Stanford University, Stanford, CA, USA.
John K EatonDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA.
Alison L MarsdenDepartment of Bioengineering, Stanford University, Stanford, CA, USA. amarsden@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePulmonary valve replacement (PVR) using bioprosthetic valves is a common procedure performed in patients with repaired Tetralogy of Fallot and other conditions, but these valves frequently become dysfunctional within 15 years of implantation. The causes for early valve failure are not clearly understood. The purpose of this study was to explore the impact of changing cardiac output (CO) and valve orientation on local hemodynamics and valve performance.

methodsA 25 mm bioprosthetic valve was implanted in an idealized 3D-printed model of the right ventricular outflow tract (RVOT). The local hemodynamics at three COs and two valve orientations were assessed using 4D-Flow MRI and high-speed camera imaging.

resultsNoticeable differences in jet asymmetry, the amount of recirculation, leaflet opening patterns, as well as the size and location of reversed flow regions were observed with varying CO. Rotation of the valve resulted in drastic differences in reversed flow regions, but not forward flow.

conclusionFlow features observed in the valve with low CO in this study have previously been correlated with calcification, hemolysis, and leaflet fatigue, indicating their potential negative impact on local hemodynamics and leaflet performance.

Indexed as

BioprosthesisCardiac OutputHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHemodynamicsMagnetic Resonance ImagingPulmonary ValveBlood Flow VelocityHumansModels, CardiovascularPredictive Value of TestsPrinting, Three-DimensionalProsthesis DesignProsthesis Failure4D-Flow MRIBioprosthetic heart valvesHigh-speed camera imagingTetralogy of Fallot

Identifiers

PMID39633206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.