Evidence map›Paper›PMID 39633075›Full record

ArticleBiogerontology2024

Nicotinamide mononucleotide suppresses cellular senescence and increases aquaporin 5 expression in the submandibular gland of aged male mice to ameliorate aging-related dry mouth.

Jun Wakabayashi, Takahiro Hamaguchi, Masashi Morifuji, Masashi Nagata

Abstract read
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In one paragraph

Article in Biogerontology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Organoid-based modeling and regenerative strategies for salivary gland dysfunction.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jun WakabayashiWellness Science Labs, Meiji Holdings Co., Ltd, 1-29-1 Nanakuni, Hachioji, Tokyo, 192-0919, Japan.
Takahiro HamaguchiWellness Science Labs, Meiji Holdings Co., Ltd, 1-29-1 Nanakuni, Hachioji, Tokyo, 192-0919, Japan.
Masashi MorifujiWellness Science Labs, Meiji Holdings Co., Ltd, 1-29-1 Nanakuni, Hachioji, Tokyo, 192-0919, Japan. masashi.morifuji@meiji.com.ORCID 0000-0002-0195-4127
Masashi NagataWellness Science Labs, Meiji Holdings Co., Ltd, 1-29-1 Nanakuni, Hachioji, Tokyo, 192-0919, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dry mouth results from decreased saliva secretion due to aging or drug side effects. Decreased saliva secretion causes dryness in the oral cavity that makes swallowing difficult and increases the risk of aspiration pneumonia. There are few fundamental treatments for dry mouth. Here we investigated whether treatment of old mice with nicotinamide mononucleotide (NMN) improved factors associated with dry mouth. Young (16-week-old) and old (113-week-old) male mice were treated subcutaneously with saline or NMN (300 mg/kg) once every two days for four weeks and saliva secretion was measured. The amount of nicotinamide adenine dinucleotide (NAD

Indexed as

AgingAquaporin 5Cellular SenescenceNicotinamide MononucleotideSubmandibular GlandXerostomiaAnimalsMaleMiceMice, Inbred C57BLSalivaAqp5 protein, mouseAquaporin 5Nicotinamide MononucleotideAquaporin5Dry mouthNicotinamide adenine dinucleotideNicotinamide mononucleotideSaliva secretionSenescence

Identifiers

PMID39633075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.