Evidence map›Paper›PMID 39633070›Full record

ArticleMolecular imaging and biology2025

First-in-human Evaluation of Safety and Dosimetry of [

David Izquierdo-Garcia, Pauline Désogère, Anne L Philip, David E Sosnovik, Ciprian Catana, Peter Caravan

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

David Izquierdo-GarciaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteen St. Suite 2301, Boston, MA, 02129, USA. dizquierdogarcia@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-0763-8827
Pauline DésogèreAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteen St. Suite 2301, Boston, MA, 02129, USA.
Anne L PhilipCardiovascular Research Center, Cardiology Division, Dept. of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
David E SosnovikAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteen St. Suite 2301, Boston, MA, 02129, USA.
Ciprian CatanaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteen St. Suite 2301, Boston, MA, 02129, USA.
Peter CaravanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteen St. Suite 2301, Boston, MA, 02129, USA.

Funding

PET Imaging of ThrombusR01HL109448 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, SOSNOVIK, DAVID E · 2011 to 2025
$9.6M
Automation Equipment for Human PET Radiotracer ProductionS10OD028499 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2021 to 2021
$325k
Ministerio de Universidades Ministerio de UniversidadesNHLBI NIH HHS R01 HL109448NIH HHS R01HL109448NIH HHS S10 OD028499NIH HHS S10OD028499PolyBio Research Foundation PolyBio Research Foundation
6 · The paper itself

Abstract

purposeThis study presents for the first time in humans the biodistribution, clearance and dosimetry estimates of [ PROCEDURES: This prospective study included 8 healthy subjects to evaluate biodistribution, safety and dosimetry estimates of [

resultsSubjects were injected with 400 MBq of [

conclusionsThis study demonstrates the following properties of the [

Indexed as

Copper RadioisotopesFibrinPositron-Emission TomographyRadiometryAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesTissue DistributionYoung AdultCopper-64Copper RadioisotopesFibrinBiodistributionBlood clotsDosimetryEffective doseFibrinMagnetic resonance imaging (MRI)PET/MRIPositron emission tomography (PET)Probe

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.