ArticleNature2025
Understanding the neural code of stress to control anhedonia.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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Who cites it
20 citing papers in PubMed.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Unveiling the enigma of anxiety disorders and depression: from pathogenesis to treatment.Science China. Life sciences · 2026Review
- Establishment and Validation of a CUMS Model for Depression-like Behavior in Honeybees: A Tool for Pollinator Stress Research.Insects · 2026Article
- Non-classical NMDAR subunit GluN3A in a specialized hippocampal region regulates stress-coping strategies in male mice.Communications biology · 2026Article
- Divergent BLA engram circuits orchestrate social preference dynamics in bystander male mice with self-experienced stress.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- vCA1 SST neurons represent avoidance states that guide anxiety-related behavioral choices.bioRxiv : the preprint server for biology · 2026Article
- EEG Microstate Alterations in Anhedonia Subtypes of Major Depressive Disorder and Their Modulation by Intermittent Theta-Burst Stimulation.Depression and anxiety · 2026Article
- Distinct neural dynamics in the ventral hippocampus and medial prefrontal cortex during social information processing.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Anxiety and Beyond: Diversity in Ventral Hippocampus Circuits and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Sex differences in resilience at puberty depend upon divergent effects of a stress steroid at α4βδ GABABrain research · 2025Article
- TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus.Translational psychiatry · 2025Article
- Article
- Isoliquiritigenin as a Neuronal Radiation Mitigant: Mitigating Radiation-Induced Anhedonia Tendency Targeting Grik3/Grm8/Grin3a via Integrated Proteomics and AI-Driven Discovery.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Altered theta oscillations in basolateral amygdala and ventral hippocampus related to social defeat.BMC neuroscience · 2025Article
- "Weibing" in traditional Chinese medicine-biological basis and mathematical representation of disease-susceptible state.Acta pharmaceutica Sinica. B · 2025Review
- Mesoscale brain-wide fluctuation analysis: revealing ketamine's rapid antidepressant across multiple brain regions.Translational psychiatry · 2025Article
- Illuminating the impact of stress: In vivo approaches to track stress-related neural adaptations.Neurobiology of stress · 2025Article
- Who participates? Who frequents? Exploring the correlates of sports participation among Chinese adults: evidence from national survey.Frontiers in psychology · 2025Article
- Exploring the correlates of frequency of Tai Chi Chuan participation among Chinese adults in an urban context.Frontiers in psychology · 2025Article
- Differential directional effects between insomnia symptoms and suicidal ideation across trait depression levels: a cross-lagged network analysis among Chinese medical undergraduates.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Frances Xia *Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-7415-6620
Valeria Fascianelli *Center for Theoretical Neuroscience, Columbia University, New York, NY, USA.
Nina VishwakarmaDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Frances Grace GhingerDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Andrew KwonDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0009-0004-3398-922X
Mark M GerguesDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0483-7161
Lahin K LalaniDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Stefano FusiCenter for Theoretical Neuroscience, Columbia University, New York, NY, USA.ORCID 0000-0002-3035-6652
Mazen A KheirbekDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. mazen.kheirbek@ucsf.edu.ORCID 0000-0001-9157-7363
Funding
Hippocampal modulation of subcortical circuits in the control of emotional behaviorR01MH108623 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mazen A Kheirbek · 2016 to 2026
$6.0MCell-type, circuit and network mechanisms of adult oligodendrogenesis in memory storage and retrievalR01MH125515 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAN, JONAH R, KHEIRBEK, MAZEN A · 2021 to 2025
$3.4MCircuit dynamics supporting associative learning in the dentate gyrusR01DC019813 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A · 2021 to 2025
$2.8MHow is anxiety-related information relayed across hippocampal-prefrontal circuitsR01MH117961 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A, SOHAL, VIKAAS SINGH · 2019 to 2022
$2.3MCircuit and cellular mechanisms of adult neurogenesis in context encoding and discriminationR01MH111754 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A · 2017 to 2021
$2.0MVentral hippocampal encoding of anxiety representations is shaped by thalamic input.F99NS130927 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERGUES, MARK M · 2022 to 2023
$81kThalamic inputs modulate anxiety-related representations in the hippocampusF31MH130127 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERGUES, MARK M · 2022 to 2022
$20kNIDCD NIH HHS R01 DC019813NIMH NIH HHS F31 MH130127NIMH NIH HHS R01 MH108623NIMH NIH HHS R01 MH111754NIMH NIH HHS R01 MH117961NIMH NIH HHS R01 MH125515NINDS NIH HHS F99 NS130927
Abstract
Anhedonia, the diminished drive to seek, value, and learn about rewards, is a core feature of major depressive disorder
Indexed as
AnhedoniaStress, PsychologicalAnimalsBasolateral Nuclear ComplexCA1 Region, HippocampalFemaleMaleMiceMice, Inbred C57BLNeuronsResilience, PsychologicalReward
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.