ArticleNature2025
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer.Science (New York, N.Y.) · 2026Article
- Article
- Stem cells as an essential mediator of the exercise-tumorigenesis link.Nature reviews. Cancer · 2026Review
- Biological aging and generational shifts in early-onset cancer risk.Nature medicine · 2026Article
- Thirty-year changes and future tendencies in Asian burden of tracheal, bronchus, and lung cancer: insights from the Global Burden of Disease Study.Journal of thoracic disease · 2026Article
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- Article
- A Roadmap to Transform Lung Cancer Outcomes: Priorities in Biology, Therapeutic Innovation, Early Detection, Prevention, and Interception.Cancer discovery · 2026Review
- Translating ferroptosis into oncology: challenges, opportunities and future directions.Nature reviews. Clinical oncology · 2026Review
- NUPR1 as a central stress-adaptation node in cancer: integrating metabolic rewiring, cell death, and therapy resistance.Journal of biomedical science · 2026Review
- Review
- Article
- Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy.Nature reviews. Cancer · 2026Review
- Article
- Article
- The nephrotoxic effects of anti-cancer therapies: consensus report of the 34th Acute Disease Quality Initiative workgroup.Nature reviews. Nephrology · 2026Review
- A multi-omic approach reveals iron availability influences cell fate fidelity.npj metabolic health and disease · 2026Article
- Genomic Impacts of Biological Exposures.Journal of developmental biology · 2026Review
- KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.Cell death & disease · 2026Article
- Lipocalin 2: a double-edged sword in cellular ferroptosis.Cell biology and toxicology · 2026Review
Corrections and comments
- Erratum issued
- Update of
Authors and funding
25 authors.
Xueqian ZhuangCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-7012-3223
Qing WangVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.
Simon JoostCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alexander FerrenaInstitute for Clinical and Translational Research, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0002-9578-8683
David T HumphreysVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.ORCID 0000-0003-4140-0089
Zhuxuan LiCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Melissa BlumCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-5372-9004
Klavdija KrauseCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Selena DingCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yuna LandaisVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.
Yingqian ZhanCenter for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-3548-9227
Yang ZhaoDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-8216-6420
Ronan ChaligneComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-4332-3291
Joo-Hyeon LeeWellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7364-6422
Sebastian E CarrascoLaboratory of Comparative Pathology, Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center and Rockefeller University, New York, NY, USA.ORCID 0000-0002-1926-7296
Umeshkumar K BhanotPathology Core Facility, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-6656-1239
Richard P KocheCenter for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-6820-5083
Matthew J BottCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-0523-4028
Pekka KatajistoInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3033-4189
Yadira M Soto-FelicianoDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Thomas PisanicInstitute for NanoBioTechnology, Department of Oncology-Cancer Genetics and Epigenetics, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-5796-0836
Tiffany ThomasDepartment of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Deyou ZhengInstitute for Clinical and Translational Research, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0003-4354-5337
Emily S WongVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.ORCID 0000-0003-0315-2942
Tuomas TammelaCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. tammelat@mskcc.org.ORCID 0000-0003-3675-6961
Funding
Cycle for Survival, and the Marie-Josée and Henry R. Kravis Center for Molecular OncologyMark Foundation for Cancer Research Emerging Leader AwardNew South Wales Government Ministry of Health
Abstract
Ageing is associated with a decline in the number and fitness of adult stem cells
Indexed as
AgingBasic Helix-Loop-Helix ProteinsCarcinogenesisIronLipocalin-2Stem CellsAlveolar Epithelial CellsAnimalsDNA-Binding ProteinsDNA MethylationFemaleFerroptosisHomeostasisHumansLung NeoplasmsMaleBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsIronLipocalin-2Neoplasm ProteinsNupr1 protein, mouse
Identifiers
PMID
39633048What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.