Evidence map›Paper›PMID 39633047›Full record

ArticleNature2025

Synthetic GPCRs for programmable sensing and control of cell behaviour.

Nicholas A Kalogriopoulos, Reika Tei, Yuqi Yan, Peter M Klein, Matthew Ravalin, Bo Cai, Ivan Soltesz, Yulong Li, Alice Y Ting

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Programming T cells for intercellular genome editing.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  11. Article
  12. Journal of the American Chemical Society · 2026
    Article
  13. Review
  14. Review
  15. Review
  16. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Nicholas A Kalogriopoulos *Department of Genetics, Stanford University, Stanford, CA, USA.
Reika Tei *Department of Genetics, Stanford University, Stanford, CA, USA.
Yuqi YanPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Peter M KleinDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3232-3387
Matthew RavalinDepartment of Genetics, Stanford University, Stanford, CA, USA.
Bo CaiDepartment of Genetics, Stanford University, Stanford, CA, USA.
Ivan SolteszDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1493-3744
Yulong LiPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.ORCID 0000-0002-9166-9919
Alice Y TingDepartment of Genetics, Stanford University, Stanford, CA, USA. ayting@stanford.edu.ORCID 0000-0002-8277-5226

Funding

Molecular tools for precise manipulation of defined synaptic connectionsR01MH135934 · NIMH · STANFORD UNIVERSITY · PI Xiaoke Chen, IVAN SOLTESZ · 2024 to 2026
$4.0M
Control of Axon Initial Segment in EpilepsyR01NS121106 · NINDS · STANFORD UNIVERSITY · PI LOSONCZY, ATTILA, SOLTESZ, IVAN · 2021 to 2025
$3.4M
Bioengineering programmable and drug-controllable synthetic receptors fortunable CAR-T cell behaviorsF32CA257159 · NCI · STANFORD UNIVERSITY · PI KALOGRIOPOULOS, NICHOLAS ANTONIOS · 2021 to 2023
$205k
NCI NIH HHS F32 CA257159NIMH NIH HHS R01 MH135934NINDS NIH HHS R01 NS121106
6 · The paper itself

Abstract

Synthetic receptors that mediate antigen-dependent cell responses are transforming therapeutics, drug discovery and basic research

Indexed as

Cell MovementMacrophagesProtein EngineeringReceptors, G-Protein-CoupledSingle-Domain AntibodiesT-LymphocytesAnimalsAntigensCell DifferentiationFemaleHEK293 CellsHumansMiceNeuronsTransgenesAntigensReceptors, G-Protein-CoupledSingle-Domain Antibodies

Identifiers

PMID39633047
PMCPMC11666456

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.