Evidence map›Paper›PMID 39633037›Full record

Trial reportSleep & breathing = Schlaf & Atmung2024

Asthma and sleep disordered breathing in the pediatric adenotonsillectomy trial for snoring study.

Po-Yang Tsou, Seyni Gueye-Ndiaye, Krysta Lynn Gorman, Ariel Williamson, Sally Ibrahim, Scott Weber, David Zopf, Fauziya Hassan, Cristina Baldassari, Carlos Sendon and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Sleep & breathing = Schlaf & Atmung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02562040 (Impact of Treatment of Mild Sleep-Disordered Breathing on Children's Health), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02562040 nacompletednot on this map

Impact of Treatment of Mild Sleep-Disordered Breathing on Children's Health

TypeinterventionalSponsorBrigham and Women's HospitalRan2017 to 2022Enrolled459ConditionsSleep-Disordered BreathingArmsEarly Adenotonsillectomy (eAT), Watchful Waiting with Supportive Care (WWSC)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Po-Yang TsouDivision of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.
Seyni Gueye-NdiayeDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Krysta Lynn GormanDivision of Pediatric Pulmonology and Sleep Medicine, UH Rainbow Babies and Children's Hospital, Case Western Reserve University, 11100 Euclid Ave, Pediatric Pulmonology, MS 6006, Cleveland, OH, 44106, USA.
Ariel WilliamsonDepartment of Psychiatry and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sally IbrahimDivision of Pediatric Pulmonology and Sleep Medicine, UH Rainbow Babies and Children's Hospital, Case Western Reserve University, 11100 Euclid Ave, Pediatric Pulmonology, MS 6006, Cleveland, OH, 44106, USA.
Scott WeberDivision of Pediatric Pulmonology and Sleep Medicine, UH Rainbow Babies and Children's Hospital, Case Western Reserve University, 11100 Euclid Ave, Pediatric Pulmonology, MS 6006, Cleveland, OH, 44106, USA.
David ZopfDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Fauziya HassanSleep Disorders Center and Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA.
Cristina BaldassariDepartment of Otolaryngology, Eastern Virginia Medical School, Children's Hospital of The King's Daughters, Norfolk, VA, USA.
Carlos SendonDepartment of Pediatrics, Division of Pulmonary and Sleep Medicine, Eastern Virginia Medical School, Children's Hospital of The King's Daughters, Norfolk, VA, USA.
Rui WangDepartment of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA.
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Dongdong LiDepartment of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA.
Kristie R RossDivision of Pediatric Pulmonology and Sleep Medicine, UH Rainbow Babies and Children's Hospital, Case Western Reserve University, 11100 Euclid Ave, Pediatric Pulmonology, MS 6006, Cleveland, OH, 44106, USA. Kristie.Ross@uhhospitals.org.ORCID 0000-0001-7732-2516

Funding

NHLBI NIH HHS 1U01HL125295NHLBI NIH HHS 1U01HL125307NHLBI NIH HHS 32HL00790NHLBI NIH HHS L40HL165622
6 · The paper itself

Abstract

purposeAlthough asthma is common in children with sleep-disordered breathing (SDB), it is unclear whether and to what extent asthma is associated with SDB-related outcomes. Our objectives are to describe risk factors for asthma among children with mild SDB (mSDB) and assess the association between asthma and the severity of sleep-related outcomes.

methodsCross-sectional analyses were conducted for children aged 3-12.9 years with mSDB enrolled in Pediatric Adenotonsillectomy for Snoring Children Study. Sleep-related outcomes included SDB symptoms (Pediatric Sleep Questionnaire-Sleep-Related Breathing Disorder scale (PSQ-SRBD)), SDB-specific quality of life (OSA-18), sleepiness (modified Epworth Sleepiness Score) and polysomnographic and actigraphic measures. Asthma was defined by caregiver-reported diagnosis with current asthma symptoms and medication use, or a Composite Asthma Severity Index (CASI) score ≥ 4. Asthma was further categorized into mild (CASI < 4) and moderate-to-severe (CASI ≥ 4). Regression analyses were conducted to identify asthma risk factors and estimate the associations between mild and moderate-to-severe asthma with sleep-related outcomes.

resultsThe sample included 425 children (20.3%-Black, 17.4%-Hispanic; 51.7%-female). The prevalence of asthma was 19.1% (7.1% moderate-to-severe, 12.0% mild). Environmental tobacco smoke exposure and markers of atopy were associated with asthma in multivariable-adjusted analyses. Moderate-to-severe asthma was associated with increased OSA symptoms measured by PSQ-SRBD (adjusted effect estimate for moderate-to-severe vs. no asthma (

conclusionModerate-to-severe asthma was associated with worse QoL and greater SDB symptoms among children with mSDB. The co-occurrence of common risk factors for mSDB and asthma and worse symptoms and quality of life in children with both conditions support coordinated strategies for prevention and co-management of both disorders. CLINICAL TRIAL: Pediatric Adenotonsillectomy for Snoring (PATS), NCT02562040, https://clinicaltrials.gov/study/NCT02562040.

Indexed as

AdenoidectomyAsthmaSnoringTonsillectomyChildChild, PreschoolCross-Sectional StudiesFemaleHumansMalePolysomnographyQuality of LifeRisk FactorsSeverity of Illness IndexSleep Apnea SyndromesAsthmaChildrenPATSSleep-related outcomes

Identifiers

PMID39633037

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.