ArticleMolecular psychiatry2025
X-chromosome-wide association study for Alzheimer's disease.
Abstract read
In one paragraph
Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Chromosome X-wide association study in multiple system atrophy identifies sex-differential risk loci.Brain : a journal of neurology · 2026Article
- X chromosome-wide association studies for quantitative trait loci based on the mixture of general pedigrees and additional unrelated individuals.Briefings in bioinformatics · 2026Article
- Biobank-based genetic characterization of neurodegenerative diseases and idiopathic normal pressure hydrocephalus: insights and lessons learned from FinnGen.Molecular psychiatry · 2026Review
- Novel Insights into the Enigmatic Genetics of Male Breast Cancer in China.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- Insights into X-Linked Susceptibility to Parkinson's Disease in the South African Population.medRxiv : the preprint server for health sciences · 2025Article
- Integrative Genetic, Proteogenomic, and Multi-omics Analyses Reveal Sex-Biased Causal Genes and Drug Targets in Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2025Article
- X chromosome-wide association studies in neurological disorders: uncovering the hidden influence of the X chromosome.Frontiers in genetics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
173 authors.
Julie Le Borgne *Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.
Lissette Gomez *The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Sami HeikkinenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-6083-2402
Najaf AminNuffield Department of Population Health Oxford University, Oxford, UK.ORCID http://orcid.org/0000-0002-8944-1771
Shahzad AhmadDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-8658-3790
Seung Hoan ChoiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Joshua BisDepartment of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3409-1110
Benjamin Grenier-BoleyUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.
Omar Garcia RodriguezThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Luca KleineidamDepartment of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0009-0006-3309-6856
Juan YoungThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.ORCID http://orcid.org/0000-0002-3923-6016
Kumar Parijat TripathiDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.ORCID http://orcid.org/0000-0002-3998-599X
Lily WangDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Achintya VarmaThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Rafael Campos-MartinDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.ORCID http://orcid.org/0000-0002-1395-8571
Sven van der LeeAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1606-8643
Vincent DamotteUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.ORCID http://orcid.org/0000-0002-7321-8575
Itziar de RojasResearch Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2148-381X
Sagnik PalmalUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.
EADB, GR@ACE, DEGESCO, EADI, GERAD, DemGene, FinnGen, ADGC, CHARGE
Richard LiptonDepartment of Neurology, Albert Einstein College of Medicine, New York, NY, USA.
Eric ReimanNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.ORCID http://orcid.org/0000-0002-0705-3696
Ann McKeeDepartment of Neurology, Boston University, Boston, MA, USA.
Philip De JagerProgram in Translational Neuro-Psychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
William BushDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-9729-6519
Scott SmallTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-4777-1502
Allan LeveyDepartment of Neurology, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-3153-502X
Andrew SaykinDepartment of Radiology, Indiana University, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-1376-8532
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Marilyn AlbertDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Bradley HymanDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Ronald PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-8178-6601
Steven YounkinDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Mary SanoDepartment of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
Thomas WisniewskiCenter for Cognitive Neurology and Departments of Neurology, New York University, School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-3379-8966
Robert VassarCognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Julie SchneiderDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9482-1752
Victor HendersonDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1198-9240
Erik RobersonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Charles DeCarliDepartment of Neurology, University of California Davis, Sacramento, CA, USA.
Frank LaFerlaDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-2324-6911
James BrewerDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Russell SwerdlowUniversity of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA.ORCID http://orcid.org/0000-0003-2948-7230
Linda Van EldikSanders-Brown Center on Aging and University of Kentucky Alzheimer's Disease Research Center, Department of Neuroscience, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0002-8139-6400
Kara Hamilton-NelsonThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Henry PaulsonMichigan Alzheimer's Disease Center, Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
Adam NajPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9621-2942
Oscar LopezUniversity of Pittsburgh Alzheimer's Disease Research Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-8546-8256
Helena ChuiDepartment of Neurology, University of Southern California, Los Angeles, CA, USA.
Paul CraneDepartment of Medicine, University of Washington, Seattle, WA, USA.
Thomas GrabowskiDepartment of Neurology, University of Washington, Seattle, WA, USA.
Walter KukullDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Sanjay AsthanaGeriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA.
Suzanne CraftGerontology and Geriatric Medicine Center on Diabetes, Obesity, and Metabolism, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Stephen StrittmatterProgram in Cellular Neuroscience, Neurodegeneration & Repair, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-8188-3092
Carlos CruchagaDepartment of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA.
James LeverenzCleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-0896-0749
Alison GoateDepartment of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0576-2472
M Ilyas KambohUniversity of Pittsburgh Alzheimer's Disease Research Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-3453-1438
Peter St George-HyslopDepartment of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Disease, Temerty Faculty of Medicine, University of Toronto, and University Health Network, Toronto, ON, USA.
Otto ValladaresPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8055-2187
Amanda KuzmaPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-6064-5420
Laura CantwellPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Matthias RiemenschneiderKlinik für Psychiatrie und Psychotherapie, Saarbrücken, Germany.
John MorrisDepartment of Neurology, Washington University, St. Louis, MO, USA.
Susan SliferThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Carolina DalmassoDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.ORCID http://orcid.org/0000-0002-4901-9955
Atahualpa CastilloDivision of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK.
Fahri KüçükaliComplex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-3835-9639
Oliver PetersGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Anja SchneiderGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0001-9540-8700
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-0654-387X
Dan RujescuMartin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Halle (Saale), Germany.ORCID http://orcid.org/0000-0002-1432-313X
Norbert ScherbaumDepartment of Psychiatry and Psychotherapy, LVR-Klinikum Essen, University of Duisburg-Essen, Germany, Medical Faculty, Duisburg, Germany.ORCID http://orcid.org/0000-0003-1759-6990
Jürgen DeckertDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Steffi Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 04103, Leipzig, Germany.ORCID http://orcid.org/0000-0003-4321-6090
Lucrezia HausnerDepartment of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9009-2356
Laura Molina-PorcelAlzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic of Barcelona, Fundació Recerca Clinic Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), and University of Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0003-4068-8578
Emrah DüzelGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Timo GrimmerCenter for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine and Health, Klinikum rechts der Isar, Munich, Germany.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.ORCID http://orcid.org/0000-0003-1492-5330
Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-1057-465X
Susanne MoebusInstitute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-0072-5410
Thomas Tegos1st Department of Neurology, Medical school, Aristotle University of Thessaloniki, Thessaloniki, Makedonia, Greece.
Nikolaos ScarmeasTaub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Depatment of Neurology, Columbia University, New York, NY, USA.
Oriol Dols-IcardoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-2656-8748
Fermin MorenoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0001-5200-3164
Jordi Pérez-TurCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-9111-1712
María J BullidoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-6477-1117
Pau PastorFundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7493-8777
Raquel Sánchez-ValleAlzheimer's Disease and Other Cognitive Disorders Unit, Service of Neurology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
Victoria ÁlvarezLaboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.ORCID http://orcid.org/0000-0002-1916-2523
Mercè BoadaResearch Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-2617-3009
Pablo García-GonzálezResearch Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-0125-5403
Raquel PuertaResearch Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0002-1191-5893
Pablo MirCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-1656-302X
Luis M RealUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.ORCID http://orcid.org/0000-0003-4932-7429
Gerard Piñol-RipollUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
Jose María García-AlbercaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-2951-6644
Jose Luís RoyoDepatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain.
Eloy Rodriguez-RodriguezCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0001-7742-677X
Hilkka SoininenInstitute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-2785-9937
Alexandre de MendonçaFaculty of Medicine, University of Lisbon, Lisbon, Portugal.
Shima MehrabianClinic of Neurology, UH "Alexandrovska", Medical University-Sofia, Sofia, Bulgaria.
Latchezar TraykovClinic of Neurology, UH "Alexandrovska", Medical University-Sofia, Sofia, Bulgaria.
Jakub HortMemory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Praha, Czech Republic.ORCID http://orcid.org/0000-0002-1080-3726
Martin VyhnalekMemory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Praha, Czech Republic.
Jesper Qvist ThomassenDepartment of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-3484-9531
Yolande A L PijnenburgAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Henne HolstegeAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7688-3087
John van SwietenDepartment of Neurology, Erasmus MC, Rotterdam, The Netherlands.
Inez RamakersMaastricht University, Department of Psychiatry & Neuropsychologie, Alzheimer Center Limburg, Maastricht, The Netherlands.
Frans VerheyMaastricht University, Department of Psychiatry & Neuropsychologie, Alzheimer Center Limburg, Maastricht, The Netherlands.
Philip ScheltensAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1046-6408
Caroline GraffUnit for Hereditary Dementias, Theme Aging, Karolinska University Hospital-Solna, 171 64, Stockholm, Sweden.
Goran PapenbergAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3423-2021
Anne BolandUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, 91057, Evry, France.ORCID http://orcid.org/0000-0001-8789-5676
Jean-François DeleuzeUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, 91057, Evry, France.
Gael NicolasUniv Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Department of Genetics and CNRMAJ, F-76000, Rouen, France.ORCID http://orcid.org/0000-0001-9391-7800
Carole DufouilInserm, Bordeaux Population Health Research Center, UMR 1219, Univ. Bordeaux, ISPED, CIC 1401-EC, Univ. Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0003-2442-4476
Florence PasquierUniv. Lille, Inserm 1171, CHU Clinical and Research Memory Research Centre (CMRR) of Distalz, Lille, France.ORCID http://orcid.org/0000-0001-9880-9788
Olivier HanonUniversité de Paris, EA 4468, APHP, Hôpital Broca, Paris, France.
Stéphanie DebetteUniversity Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France.ORCID http://orcid.org/0000-0001-8675-7968
Edna GrünblattDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-8505-7265
Julius PoppOld Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.
Roberta GhidoniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, 25125, Italy.ORCID http://orcid.org/0000-0002-7691-1957
Daniela GalimbertiNeurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.ORCID http://orcid.org/0000-0002-9284-5953
Beatrice ArosioDepartment of Clinical Sciences and Community Health, University of Milan, 20122, Milan, Italy.ORCID http://orcid.org/0000-0002-0615-3580
Patrizia MecocciInstitute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID http://orcid.org/0000-0003-0729-5246
Vincenzo SolfrizziInterdisciplinary Department of Medicine, Geriatric Medicine and Memory Unit, University of Bari "A. Moro", Bari, Italy.ORCID http://orcid.org/0000-0002-8524-0315
Lucilla ParnettiCentre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.ORCID http://orcid.org/0000-0001-5722-3967
Alessio SquassinaDepartment of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.ORCID http://orcid.org/0000-0001-7415-7607
Lucio TremolizzoNeurology Unit, "San Gerardo" Hospital, Monza and University of Milano-Bicocca, Milan, Italy.
Barbara BorroniDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0001-9338-9040
Marco SpallazziDepartment of Medicine and Surgery, Unit of Neurology, University-Hospital of Parma, Parma, Italy.
Davide SeripaDepartment of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy.
Innocenzo RaineroDepartment of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy.
Antonio DanieleDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.
Paola BossùLaboratory of Experimental Neuropsychobiology, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID http://orcid.org/0000-0002-1432-0078
Carlo MasulloInstitute of Neurology, Catholic University of the Sacred Heart, Rome, Italy.
Giacomina RossiFondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Frank JessenGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Victoria FernandezResearch Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Patrick Gavin KehoeTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-7542-1139
Ruth Frikke-SchmidtDepartment of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4084-5027
Magda Tsolaki1st Department of Neurology, Medical school, Aristotle University of Thessaloniki, Thessaloniki, Makedonia, Greece.ORCID http://orcid.org/0000-0002-2072-8010
Pascual Sánchez-JuanCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Kristel SleegersComplex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-0283-2332
Martin IngelssonDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Jonathan HainesDepartment of Population and Quantitative Health Sciences and Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-4351-4728
Lindsay FarrerDepartment of Neurology, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5533-4225
Richard MayeuxTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-6519-9696
Li-San WangDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Rebecca SimsDivision of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK.ORCID http://orcid.org/0000-0002-3885-1199
Anita DeStefanoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Gerard D SchellenbergPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sudha SeshadriGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-6135-2622
Philippe AmouyelUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.ORCID http://orcid.org/0000-0001-9088-234X
Julie WilliamsDivision of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK.ORCID http://orcid.org/0000-0002-4069-0259
Wiesje van der FlierAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-8766-6224
Alfredo RamirezDepartment of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-4991-763X
Margaret Pericak-VanceThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Ole A AndreassenNORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Cornelia Van DuijnNuffield Department of Population Health Oxford University, Oxford, UK.ORCID http://orcid.org/0000-0002-2374-9204
Mikko HiltunenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Agustín RuizResearch Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-2633-2495
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2871-3603
Eden MartinThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Jean-Charles LambertUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.ORCID http://orcid.org/0000-0003-0829-7817
Brian KunkleThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Céline BellenguezUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France. celine.bellenguez@pasteur-lille.fr.ORCID http://orcid.org/0000-0002-1240-7874
Funding
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MAlzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MNational Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8MTHE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITEU24AG041689 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LI-SAN WANG · 2012 to 2026
$42.3MUCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9MResearch Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0MYale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2MResearch Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR · 2021 to 2026
$26.3MRush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7MTransgenic/Behavior CoreP01AG060882 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHAO, YONGZHAO · 2020 to 2024
$12.0MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MGenome Wide associate analysis of Alzheimer's DiseaseRC2AG036528 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2010
$5.4MNHLBI NIH HHS R01 HL105756NIA NIH HHS P01 AG060882NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072977NIA NIH HHS R01 AG062634NIA NIH HHS RC2 AG036528NIA NIH HHS U01 AG032984NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG041689NIA NIH HHS U24 AG072122
Abstract
Due to methodological reasons, the X-chromosome has not been featured in the major genome-wide association studies on Alzheimer's Disease (AD). To address this and better characterize the genetic landscape of AD, we performed an in-depth X-Chromosome-Wide Association Study (XWAS) in 115,841 AD cases or AD proxy cases, including 52,214 clinically-diagnosed AD cases, and 613,671 controls. We considered three approaches to account for the different X-chromosome inactivation (XCI) states in females, i.e. random XCI, skewed XCI, and escape XCI. We did not detect any genome-wide significant signals (P ≤ 5 × 10
Indexed as
Alzheimer DiseaseChromosomes, Human, XAgedAged, 80 and overCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideX Chromosome Inactivation
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