ArticleScientific reports2024
Development of a controlled-release mosquito RNAi yeast larvicide suitable for the sustained control of large water storage containers.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Targeting the Highly Invasive Malaria Vector Anopheles stephensi using Yeast RNAi Pesticides.Research square · 2026Article
- Development of an eco-friendly RNAi yeast attractive targeted sugar bait that silences the shaker gene in spotted-wing drosophila, Drosophila suzukii.Pest management science · 2026Article
- Single-Cell oils from oleaginous yeasts: a scalable biotechnological source of novel larvicides against Aedes aegypti.World journal of microbiology & biotechnology · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
Large household water storage containers are among the most productive habitats for Aedes aegypti (Linnaeus, 1762), the primary mosquito vector for dengue and other arboviral pathogens. Increasing concerns for insecticide resistance and larvicide safety are limiting the successful treatment of large household water storage containers, which are among the most productive habitats for Aedes juveniles. The recent development of species-specific RNAi-based yeast larvicides could help overcome these problems, particularly if shelf stable ready-to-use formulations with significant residual activity in water can be developed. Here we examine the hypothesis that development of a shelf-stable controlled-release RNAi yeast formulation can facilitate lasting control of A. aegypti juveniles in large water storage containers. In this study, a dried inactivated yeast was incorporated into a biodegradable matrix containing a mixture of polylactic acid, a preservative, and UV protectants. The formulation was prepared using food-grade level components to prevent toxicity to humans or other organisms. Both floating and sinking versions of the tablets were prepared for treatment of various sized water containers, including household water storage tank-sized containers. The tablets passed accelerated storage tests of shelf life stability and demonstrated up to six months residual activity in water. The yeast performed well in both small and large containers, including water barrels containing 20-1000 larvae each, and in outdoor barrel trials. Future studies will include the evaluation of the yeast larvicide in larger operational field trials that will further assess the potential for incorporating this new technology into integrated mosquito control programs worldwide.
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