Evidence map›Paper›PMID 39632963›Full record

ArticleScientific reports2024

The anti-tumor effects of main component (benzethonium chloride) of butorphanol tartrate injection in non-small cell lung cancer.

Honglei Tao, Lei Li, Huiling Li, Tingting Ma, Xinping Zhu, Jili Cao, Yongqiang Zhu, Shengmei Zhu, Mingqian Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Honglei Tao *Department of Anesthesiology, The First Affiliated Hospital, ZheJiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.
Lei Li *Department of Anesthesiology, The First Affiliated Hospital, ZheJiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.
Huiling Li *Department of Anesthesiology, The First Affiliated Hospital, ZheJiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.
Tingting MaZhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.
Xinping ZhuZhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.
Jili CaoZhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.
Yongqiang ZhuZhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.
Shengmei ZhuDepartment of Anesthesiology, The First Affiliated Hospital, ZheJiang University School of Medicine, Hangzhou, 310009, Zhejiang, China. smzhu20088@zju.edu.cn.
Mingqian LiZhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China. limingqian613@163.com.

Funding

National Natural Science Foundation of China 82074093Zhejiang Traditional Chinese Medicine Administration 2021AX002
6 · The paper itself

Abstract

Cancer is one of the leading causes of morbidity and mortality in the global population. The effective management of cancer-associated pain and anesthesia are critical aspects of comprehensive cancer treatment. However, the role and mechanism of anesthesia and analgesia-related drugs in tumors remain controversial. In this study, the efficacy of 16 commonly used analgesics and anesthetics against non-small cell lung cancer (NSCLC) was evaluated. Among the 16 examined injections, butorphanol tartrate injection significantly inhibited the proliferation of NSCLC cells and increased the sensitivity of the EGFR-TKI-resistant H1975 cell line to gefitinib. Benzethonium chloride (BC) is the main active antitumor ingredient of butorphanol tartrate injection. BC may regulate the cell cycle, apoptosis and EMT signaling pathways by modulating the P53 signaling pathway. Our study reveals the therapeutic value of butorphanol tartrate injection and BC in the treatment of NSCLC and provides a theoretical basis for comprehensive therapies for NSCLC.

Indexed as

ApoptosisBenzethoniumButorphanolCarcinoma, Non-Small-Cell LungCell ProliferationLung NeoplasmsAnimalsAntineoplastic AgentsCell Line, TumorGefitinibHumansSignal TransductionAntineoplastic AgentsBenzethoniumButorphanolGefitinibBenzethonium chlorideButorphanol tartrate injectionNon-small cell lung cancerP53 signaling pathway

Identifiers

PMID39632963
PMCPMC11618660

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.