ArticleNature communications2024
Orthogonalization of spontaneous and stimulus-driven activity by hierarchical neocortical areal network in primates.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Population coding under the scale invariance of high-dimensional noise.Science advances · 2026Article
- Exploring neural manifolds across a wide range of intrinsic dimensions.PLoS computational biology · 2026Article
- State-Dependent Dissociation of Shared Input and Directed Information Flow in the Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- ARViS: a bleed-free multi-site automated injection robot for accurate, fast, and dense delivery of virus to mouse and marmoset cerebral cortex.Nature communications · 2024Article
- Dynamics of directional motor tuning in the primate premotor and primary motor cortices during sensorimotor learning.Nature communications · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
How biological neural networks reliably process information in the presence of spontaneous activity remains controversial. In mouse primary visual cortex (V1), stimulus-evoked and spontaneous activity show orthogonal (dissimilar) patterns, which is advantageous for separating sensory signals from internal noise. However, studies in carnivore and primate V1, which have functional columns, have reported high similarity between stimulus-evoked and spontaneous activity. Thus, the mechanism of signal-noise separation in the columnar visual cortex may be different from that in rodents. To address this issue, we compared spontaneous and stimulus-evoked activity in marmoset V1 and higher visual areas. In marmoset V1, spontaneous and stimulus-evoked activity showed similar patterns as expected. However, in marmoset higher visual areas, spontaneous and stimulus-evoked activity were progressively orthogonalized along the cortical hierarchy, eventually reaching levels comparable to those in mouse V1. These results suggest that orthogonalization of spontaneous and stimulus-evoked activity is a general principle of cortical computation.
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