Evidence map›Paper›PMID 39632796›Full record

ArticleTranslational psychiatry2024

Impacts of CACNB4 overexpression on dendritic spine density in both sexes and relevance to schizophrenia.

Emily M Parker, Nathan L Kindja, Rebecca A DeGiosio, Ryan B Salisbury, Josh M Krivinko, Claire E J Cheetham, Matthew L MacDonald, Weijia Fan, Bin Cheng, Robert A Sweet

Abstract read
In one paragraph

Article in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emily M ParkerCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-7775-9742
Nathan L KindjaTranslational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA, USA.
Rebecca A DeGiosioCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
Ryan B SalisburyTranslational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA, USA.
Josh M KrivinkoTranslational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA, USA.
Claire E J CheethamCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
Matthew L MacDonaldCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
Weijia FanDepartment of Biostatistics, Columbia University, New York, NY, USA.
Bin ChengDepartment of Biostatistics, Columbia University, New York, NY, USA.
Robert A SweetCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA. sweetra@upmc.edu.ORCID 0000-0001-9154-9709

Funding

Training in Schizophrenia and Psychotic Disorders: From Animal Models to PatientsT32MH018870 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Guillermo Horga, Christoph Kellendonk · 1988 to 2026
$9.8M
Plasticity of Auditory Cortical Circuits in SchizophreniaR01MH071533 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 2004 to 2018
$6.9M
Synaptic Protein Networks, Genetic Risk, and Spine Loss in SchizophreniaR01MH118497 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MACDONALD, MATTHEW L · 2019 to 2023
$2.5M
CACNB4 overexpression and a mechanism for dendritic spine loss in schizophreniaF31MH117834 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PARKER, EMILY MEREDITH · 2019 to 2020
$63k
NIMH NIH HHS F31 MH117834NIMH NIH HHS R01 MH071533NIMH NIH HHS R01 MH118497NIMH NIH HHS T32 MH018870U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 1R01MH118497-01A1U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 5F31MH117834-02U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 5R01MH071533-09U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) T32-MH018870
6 · The paper itself

Abstract

The voltage-gated calcium channel (VGCC) subunit complex is comprised of the α1 subunit, the ion-permeable channel, and three auxiliary subunits: β, α

Indexed as

Dendritic SpinesSchizophreniaAnimalsAuditory CortexCalcium Channels, L-TypeCalcium Channels, N-TypeFemaleHumansMaleMiceMice, Inbred C57BLCalcium Channels, L-TypeCalcium Channels, N-Type

Identifiers

PMID39632796
PMCPMC11618769

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.