Evidence map›Paper›PMID 39632478›Full record

ArticleDigestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society2025

Efficacy of endoscopic radiofrequency ablation for proton pump inhibitor-dependent gastroesophageal reflux disease: Multicenter prospective cohort study.

Yuanxi Jiang, Zhiyu Dong, Ying Chen, Huihui Sun, Junwen Wang, Zhenxiang Wang, Qianqian Meng, Han Lin, Qingwei Zhang, Shengliang Chen and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuanxi JiangDepartment of Gastroenterology, Tongji Hospital，School of Medicine, Tongji University, Shanghai, China.
Zhiyu DongDepartment of Gastroenterology, Tongji Hospital，School of Medicine, Tongji University, Shanghai, China.
Ying ChenDepartment of Gastroenterology, Tongji Hospital，School of Medicine, Tongji University, Shanghai, China.
Huihui SunDepartment of Gastroenterology, Tongji Hospital，School of Medicine, Tongji University, Shanghai, China.
Junwen WangDepartment of Gastroenterology, Tongji Hospital，School of Medicine, Tongji University, Shanghai, China.
Zhenxiang WangDepartment of Gastroenterology, Tongji Hospital，School of Medicine, Tongji University, Shanghai, China.
Qianqian MengDepartment of Gastroenterology, Digestive Endoscopy Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Han LinDepartment of Gastroenterology, Digestive Endoscopy Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Qingwei ZhangKey Laboratory of Gastroenterology and Hepatology, Division of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Shanghai, China.
Shengliang ChenKey Laboratory of Gastroenterology and Hepatology, Division of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Shanghai, China.
Zhizheng GeKey Laboratory of Gastroenterology and Hepatology, Division of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Shanghai, China.
Luowei WangDepartment of Gastroenterology, Digestive Endoscopy Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Shuchang XuDepartment of Gastroenterology, Tongji Hospital，School of Medicine, Tongji University, Shanghai, China.

Funding

Clinical Research Plan of SHDC SHDC2022CRT004Science and Technology Innovation Action Plan of STCSM 22DZ2203900Shanghai Municipal Health Commission 202040079Shanghai Shenkang Hospital Development Center SHDC12016109
6 · The paper itself

Abstract

objectivesTo evaluate the effects of endoscopic radiofrequency ablation (RFA) on proton pump inhibitor (PPI)-dependent gastroesophageal reflux disease (GERD) in a Chinese population, and to explore the factors associated with favorable efficacy.

methodsA multicenter, single-armed prospective cohort study was conducted. PPI-dependent GERD patients were enrolled and underwent RFA. The primary outcome was improvement of GERD health-related quality of life (GERD-HRQL). Secondary outcomes were symptom improvement, satisfaction, PPI use, and the indicators of 24-h pH-impedance monitoring. A nomogram to predict complete remission was constructed.

resultsIn total, 66 patients were included. The GERD-HRQL score was significantly reduced at the 3 month (mean difference, 14.7 [12.6-16.9]), 6 month (mean difference, 15.9 [13.8-18.1]), 12 month (mean difference, 16.7 [14.4-18.9]), 24 month (mean difference, 18.4 [16.2-20.1]), 36 month (mean difference, 18.2 [16.3-20.4]), and 48 month follow-up (mean difference, 16.1 [14.2-18.3]), all P < 0.001. The esophageal and extra-esophageal symptom scores were all significantly decreased. The proportion of satisfaction and no PPI use were significantly higher. With regard to the indicators of 24-h pH-impedance monitoring, acid exposure time (AET), and DeMeester score, but not lower esophageal sphincter (LES) pressure, decreased significantly at the 12 month follow-up. A nomogram based on age, body mass index (BMI), baseline AET, and LES pressure was then constructed and showed good discrimination in the prediction of complete remission following RFA.

conclusionsThis study demonstrated that RFA improved life quality as well as symptoms in PPI-dependent GERD patients in a Chinese population. Younger age, higher BMI, lower baseline AET, and higher baseline LES pressure indicate favorable efficacy of RFA.

Indexed as

Catheter AblationGastroesophageal RefluxProton Pump InhibitorsRadiofrequency AblationAdultAgedEsophageal pH MonitoringFemaleHumansMaleMiddle AgedProspective StudiesQuality of LifeTreatment OutcomeProton Pump Inhibitorsdependentendoscopic radiofrequencygastroesophageal reflux diseaseGERD‐HRQLproton pump inhibitor

Identifiers

PMID39632478
PMCPMC12062556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.