Evidence map›Paper›PMID 39631928›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2024

Respiratory muscle dysfunction in acute and chronic respiratory failure: how to diagnose and how to treat?

Diego Poddighe, Marine Van Hollebeke, Antenor Rodrigues, Greet Hermans, Dries Testelmans, Alexandros Kalkanis, Beatrix Clerckx, Ghislaine Gayan-Ramirez, Rik Gosselink, Daniel Langer

Abstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Observational
  10. Article
  11. Article
  12. The role of the pulmonary function laboratory in the assessment of adults with neuromuscular disease.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025
    Article
  13. Article
  14. Observational
  15. Ultrasound innovations in diaphragm assessment: an integrative review of expanding clinical applications.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  16. Article
  17. Diaphragm excursion and diaphragm thickening fraction: commonality and conflict.European respiratory review : an official journal of the European Respiratory Society · 2025
    Article
  18. Reply to: Diaphragm excursion and diaphragm thickening fraction: commonality and conflict.European respiratory review : an official journal of the European Respiratory Society · 2025
    Article
  19. Article
  20. Feasibility Analysis of a Portable Diaphragmatic Efficiency Monitor for CSCI Patients.IEEE journal of translational engineering in health and medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Diego PoddigheKU Leuven, Department of Rehabilitation Sciences, Research Group for Rehabilitation in Internal Disorders, Leuven, Belgium.ORCID https://orcid.org/0000-0003-0428-3338
Marine Van HollebekeKU Leuven, Department of Rehabilitation Sciences, Research Group for Rehabilitation in Internal Disorders, Leuven, Belgium.ORCID https://orcid.org/0000-0002-9749-569X
Antenor RodriguesKeenan Centre for Biomedical Research, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, ON, Canada.
Greet HermansUniversity Hospitals Leuven, Department of General Internal Medicine, Medical Intensive Care Unit, Leuven, Belgium.
Dries TestelmansUniversity Hospitals Leuven, Department of Respiratory Medicine, Leuven, Belgium.ORCID https://orcid.org/0000-0001-7303-9799
Alexandros KalkanisUniversity Hospitals Leuven, Department of Respiratory Medicine, Leuven, Belgium.
Beatrix ClerckxUniversity Hospitals Leuven, Department of General Internal Medicine, Medical Intensive Care Unit, Leuven, Belgium.
Ghislaine Gayan-RamirezKU Leuven, Department of Chronic Diseases and Metabolism (CHROMETA), Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Leuven, Belgium.
Rik GosselinkKU Leuven, Department of Rehabilitation Sciences, Research Group for Rehabilitation in Internal Disorders, Leuven, Belgium.ORCID https://orcid.org/0000-0003-0444-8606
Daniel LangerKU Leuven, Department of Rehabilitation Sciences, Research Group for Rehabilitation in Internal Disorders, Leuven, Belgium daniel.langer@kuleuven.be.ORCID https://orcid.org/0000-0001-8738-9482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assessing and treating respiratory muscle dysfunction is crucial for patients with both acute and chronic respiratory failure. Respiratory muscle dysfunction can contribute to the onset of respiratory failure and may also worsen due to interventions aimed at treatment. Evaluating respiratory muscle function is particularly valuable for diagnosing, phenotyping and assessing treatment efficacy in these patients. This review outlines established methods, such as measuring respiratory pressures, and explores novel techniques, including respiratory muscle neurophysiology assessments using electromyography and imaging with ultrasound.Additionally, we review various treatment strategies designed to support and alleviate the burden on overworked respiratory muscles or to enhance their capacity through training interventions. These strategies range from invasive and noninvasive mechanical ventilation approaches to specialised respiratory muscle training programmes. By summarising both established techniques and recent methodological advancements, this review aims to provide a comprehensive overview of the tools available in clinical practice for evaluating and treating respiratory muscle dysfunction. Our goal is to present a clear understanding of the current capabilities and limitations of these diagnostic and therapeutic approaches. Integrating advanced diagnostic methods and innovative treatment strategies should help improve patient management and outcomes. This comprehensive review serves as a resource for clinicians, equipping them with the necessary knowledge to effectively diagnose and treat respiratory muscle dysfunction in both acute and chronic respiratory failure scenarios.

Indexed as

Predictive Value of TestsRespiratory InsufficiencyRespiratory MusclesAcute DiseaseBreathing ExercisesChronic DiseaseHumansLungRecovery of FunctionRespiration, ArtificialTreatment Outcome

Identifiers

PMID39631928
PMCPMC11615664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.