Evidence map›Paper›PMID 39631867›Full record

ReviewInternal medicine (Tokyo, Japan)2025

Cutaneous Squamous Cell Carcinoma Producing Granulocyte Colony-stimulating Factor and Parathyroid Hormone-related Protein: A Case Report and Literature Review.

Takuya Kumagai, Masaya Saito, Takahiko Sato, Junichi Inoue, Norihisa Ishikawa, Tsuyoshi Ono, Michihiro Kono, Naoto Takahashi

Abstract readCase ReportsReview
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takuya KumagaiDepartment of Internal Medicine, Municipal Omori Hospital, Japan.
Masaya SaitoDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
Takahiko SatoDepartment of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine, Japan.
Junichi InoueDepartment of Orthopedic Surgery, Municipal Omori Hospital, Japan.
Norihisa IshikawaDepartment of Dermatology, Omagari Kousei Medical Center, Japan.
Tsuyoshi OnoDepartment of Internal Medicine, Municipal Omori Hospital, Japan.
Michihiro KonoDepartment of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine, Japan.
Naoto TakahashiDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a case of cutaneous squamous cell carcinoma (SCC) characterized by paraneoplastic hypercalcemia-leukocytosis syndrome. The patient presented with systemic symptoms, including anorexia, a fever, and a tumoral lesion on the upper arm. Laboratory test results revealed hypercalcemia and leukocytosis. A tissue biopsy confirmed SCC, and further investigation revealed elevated parathyroid hormone-related protein (PTHrP) and granulocyte-colony stimulating factor (G-CSF) levels. Immunostaining demonstrated G-CSF production by the tumor cells. Radiation therapy was administered, which improved leukocytosis and decreased G-CSF and PTHrP levels. Through a case report and literature review, we explored the clinical characteristics of tumors that produce G-CSF and PTHrP.

Indexed as

Carcinoma, Squamous CellGranulocyte Colony-Stimulating FactorParathyroid Hormone-Related ProteinSkin NeoplasmsHumansHypercalcemiaLeukocytosisParaneoplastic SyndromesGranulocyte Colony-Stimulating FactorParathyroid Hormone-Related Proteingranulocyte-colony stimulating factorhypercalcemia-leukocytosis syndromeparaneoplastic syndromeparathyroid hormone-related protein

Identifiers

PMID39631867
PMCPMC12241772

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.