Evidence map›Paper›PMID 39631864›Full record

ArticleInternal medicine (Tokyo, Japan)2025

A Re-evaluation of Renal Biopsy-based Diagnoses Through a Genetic Analysis in Two Families with Alport Syndrome.

Yoshiaki Higashi, Kenichi Koga, Masako Hasebe, Chiho Fukushima, Chiaki Omiya, Keisuke Nishioka, Kandai Nozu, Kensei Yahata

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yoshiaki HigashiDepartment of Nephrology, Osaka Red Cross Hospital, Japan.
Kenichi KogaDepartment of Nephrology, Osaka Red Cross Hospital, Japan.
Masako HasebeDepartment of Nephrology, Osaka Red Cross Hospital, Japan.
Chiho FukushimaDepartment of Nephrology, Osaka Red Cross Hospital, Japan.
Chiaki OmiyaDepartment of Nephrology, Osaka Red Cross Hospital, Japan.
Keisuke NishiokaDepartment of Nephrology, Osaka Red Cross Hospital, Japan.
Kandai NozuDepartment of Pediatrics, Kobe University Graduate School of Medicine, Japan.
Kensei YahataDepartment of Nephrology, Osaka Red Cross Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alport syndrome is an inherited disorder characterized by progressive renal failure, sensorineural hearing loss, and ocular involvement due to pathogenic variants of genes encoding type IV collagen. A renal biopsy does not reveal specific findings in the early stages; thus, Alport syndrome may be diagnosed as another glomerular disease. We herein report two families that were previously diagnosed with other glomerular diseases based on renal biopsies and were then accurately diagnosed by genetic testing. An early diagnosis may lead to the avoidance of unnecessary biopsies and treatments, and appropriate management may improve the renal prognosis.

Indexed as

Genetic TestingKidneyNephritis, HereditaryBiopsyCollagen Type IVFemaleHumansMalePedigreeCollagen Type IVAlport syndromegenetic testingrenal biopsy

Identifiers

PMID39631864
PMCPMC12287572

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.