Evidence map›Paper›PMID 39631782›Full record

ArticleJournal of microbiology and biotechnology2024

Ischemic Stroke Induces ROS Accumulation, Maladaptive Mitophagy, and Neuronal Apoptosis in Minipigs.

Jie Chen, Yanan Bie, Yajin Guan, Wen Liu, Fei Xu, Tianping Liu, Zilong Meng, Mengqi Gao, Jiawei Liu, Shuilin Xie and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jie ChenGuangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529000, P.R. China.
Yanan BieSchool of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510000, P.R. China.
Yajin GuanGuangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529000, P.R. China.
Wen LiuInstitute of Comparative Medicine & Laboratory Animal Management Center, Southern Medical University, Guangzhou 510000, P.R. China.
Fei XuGuangdong Mingzhu Biotechnology Co., Ltd., Foshan 528000, P.R. China.
Tianping LiuGuangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529000, P.R. China.
Zilong MengGuangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529000, P.R. China.
Mengqi GaoInstitute of Neuroscience, Department of Neurosurgery the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, P.R. China.
Jiawei LiuGuangDong 999 Brain Hospital, Guangzhou 510000, P.R. China.
Shuilin XieSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, P.R. China.
Weiwang GuGuangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species (ROS)-induced adaptive/maladaptive mitophagy plays an essential role in the pathophysiology of acute ischemic stroke (AIS). However, most studies have been conducted using rodent models, which limits their clinical application. In this study, we aimed to develop porcine models of permanent stroke and observe the pathophysiological alterations caused by acute ischemic stroke, focusing on ROS-induced mitophagy. Miniature pigs were subjected to lateral frontotemporal electrocoagulation, which resulted in permanent middle cerebral artery occlusion. We investigated global brain damage and mechanisms of adaptive/maladaptive mitophagy caused by ROS and global brain inflammation after AIS. An early neuroinflammatory response was observed in the ipsilateral hemisphere. ROS levels were significantly elevated in the ipsilateral hemisphere and slightly elevated in the contralateral hemisphere. ROS accumulation may be attributed to the increased production and impaired elimination of ROS. In addition, mitophagy and apoptosis were detected in the ischemic core, which may be attributed to ROS accumulation. We propose "distinct-area targeting" interventions aimed at maladaptive mitophagy within the ischemic core of the infarct hemisphere, which may provide new therapeutic targets for the treatment of AIS.

Indexed as

ApoptosisDisease Models, AnimalIschemic StrokeMitophagyNeuronsReactive Oxygen SpeciesSwine, MiniatureAnimalsBrainBrain IschemiaInfarction, Middle Cerebral ArteryMaleMitochondriaSwineReactive Oxygen Speciesacute ischemic strokemaladaptive mitophagyminipigneuronal apoptosisReactive oxygen species accumulation

Identifiers

PMID39631782
PMCPMC11729333

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.