Evidence map›Paper›PMID 39631550›Full record

Observational studyRespiratory medicine2025

Peripheral airways dysfunction measured by oscillometry differentiates asthma from inducible laryngeal obstruction.

Patrick Donohue, Margaret Connolly, Marcus D'Alfonso, Gerriann Jackson, Liane C Grasso, Xueya Cai, Ashley P O'Connell Ferster, G Todd Schneider, Sandhya Khurana, Steve N Georas

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Respiratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patrick DonohueDivision of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY, 14642, USA; Mary Parkes Center for Asthma, Allergy & Pulmonary Care, 400 Red Creek Drive, Suite 110, Rochester, NY, 14623, USA. Electronic address: Patrick_donohue@urmc.rochester.edu.
Margaret ConnollyDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Maryland Medical Center, 22 South Greene Street, Baltimore, MD, 21201, USA. Electronic address: maconnolly@som.umaryland.edu.
Marcus D'AlfonsoDivision of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY, 14642, USA. Electronic address: marcus_dalfonso@urmc.rochester.edu.
Gerriann JacksonDepartment of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY, 14642, USA. Electronic address: gerriann_jackson@urmc.rochester.edu.
Liane C GrassoDepartment of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY, 14642, USA. Electronic address: Liane_Grasso@urmc.rochester.edu.
Xueya CaiDepartment of Biostatistics and Computational Biology, 265 Crittenden Boulevard, CU 420630, Rochester, NY, 14642, USA. Electronic address: Xueya_Cai@urmc.rochester.edu.
Ashley P O'Connell FersterDepartment of Otolaryngology-Head and Neck Surgery, Tufts Medical Center, 800 Washington Street, Boston, MA, 02111, USA. Electronic address: Ashley.oconnellferster@tuftsmedicalcenter.org.
G Todd SchneiderDepartment of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY, 14642, USA. Electronic address: glenn_schneider@urmc.rochester.edu.
Sandhya KhuranaDivision of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY, 14642, USA; Mary Parkes Center for Asthma, Allergy & Pulmonary Care, 400 Red Creek Drive, Suite 110, Rochester, NY, 14623, USA. Electronic address: sandhya_khurana@urmc.rochester.edu.
Steve N GeorasDivision of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY, 14642, USA; Mary Parkes Center for Asthma, Allergy & Pulmonary Care, 400 Red Creek Drive, Suite 110, Rochester, NY, 14623, USA. Electronic address: steve_georas@urmc.rochester.edu.

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026
$42.8M
MULTIDISCIPLINARY TRAINING IN PULMONARY RESEARCHT32HL066988 · NHLBI · UNIVERSITY OF ROCHESTER · PI GEORAS, STEVE N, O'REILLY, MICHAEL A · 2001 to 2021
$8.1M
NHLBI NIH HHS T32 HL066988NIEHS NIH HHS P30 ES001247
6 · The paper itself

Abstract

backgroundInducible laryngeal obstruction (ILO, also called vocal cord dysfunction) can be difficult to distinguish clinically from asthma. Limited studies have explored the use of respiratory oscillometry to detect changes unique to ILO, but more study is needed to determine if routine oscillometry can differentiate these two clinical entities.

objectiveDetermine if impedance variables measured on routine oscillometry over tidal breathing vary between individuals with asthma and ILO.

methodsSubjects with asthma and ILO were recruited to participate in a single-center, observational study at the University of Rochester Medical Center. Oscillometry measurements were obtained over tidal breathing according to technical standards. Exploratory oscillometry variables were analyzed, as well as standard oscillometry variables including measures of peripheral airways dysfunction.

results25 subjects (12 with asthma and 13 with ILO) were recruited and included in the analysis. Measures of peripheral airways dysfunction including frequency dependence of resistance (R5-R20), area under the reactance curve (AX), and reactance at 5 Hz (X5) were significantly more abnormal in asthma subjects compared to ILO subjects (p = 0.039, p = 0.008, and p = 0.0327 respectively). Resistance at 5 Hz (R5) was not statistically different between asthma and ILO (p = 0.301). Exploratory variables, including inspiratory impedance and the standard deviation of impedance, were not significantly different between asthma and ILO.

conclusionMeasures of peripheral airways dysfunction by oscillometry were significantly different in subjects with asthma compared to ILO and more significant in subjects with poor asthma control. There were no exploratory oscillometry variables that were significantly different between ILO and asthma.

Indexed as

AsthmaOscillometryVocal Cord DysfunctionAdultAgedAirway ObstructionAirway ResistanceDiagnosis, DifferentialFemaleHumansMaleMiddle AgedRespiratory Function TestsAsthmaInducible laryngeal obstructionOscillometryPhysiologyVocal cord dysfunction

Identifiers

PMID39631550
PMCPMC11700764

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.