Evidence map›Paper›PMID 39631441›Full record

ArticleACS synthetic biology2024

Toward a Quadruplet Codon Mitochondrial Genetic Code.

Michael L Pigula, Yahui Ban, Peter G Schultz

Abstract read
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael L PigulaDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Rd, La Jolla, California 92037, United States.
Yahui BanDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Rd, La Jolla, California 92037, United States.ORCID 0009-0006-2122-3395
Peter G SchultzDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Rd, La Jolla, California 92037, United States.ORCID 0000-0003-3188-1202

Funding

Synthesis at the Interface of Chemistry and BiologyR35GM145323 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI PETER G SCHULTZ · 2022 to 2026
$3.4M
NIGMS NIH HHS R35 GM145323
6 · The paper itself

Abstract

Nature has evolved to exclusively use a genetic code consisting of triplet nucleotide codons. The translation system, however, is known to be compatible with 4-nucleotide frameshift or quadruplet codons. In this study, we begin to explore the possibility of a genome made up entirely of quadruplet codons using the minimal mitochondrial genome of

Indexed as

CodonGenetic CodeMitochondriaSaccharomyces cerevisiaeAnticodonElectron Transport Complex IVGenetic EngineeringGenome, MitochondrialProtein BiosynthesisRNA, TransferAnticodonCodonElectron Transport Complex IVRNA, Transfergenome recodingmitochondriaquadruplet codontRNA engineering

Identifiers

PMID39631441
PMCPMC11792677

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.