Evidence map›Paper›PMID 39631179›Full record

ArticleCortex; a journal devoted to the study of the nervous system and behavior2025

Non-right-handedness, male sex, and regional, network-specific, ventral occipito-temporal anomalous lateralization in adults with a history of reading disability.

Zachary A Miller, Leighton B N Hinkley, Valentina Borghesani, Ezra Mauer, Wendy Shwe, Danielle Mizuiri, Rian Bogley, Maria Luisa Mandelli, Jessica de Leon, Christa Watson Pereira and 6 more

Abstract read
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Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zachary A MillerMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Electronic address: Zachary.Miller2@ucsf.edu.
Leighton B N HinkleyDepartment of Radiology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: Leighton.Hinkley@ucsf.edu.
Valentina BorghesaniUniversity of Geneva, Swiss National Centre of Competence in Research, Geneva, Switzerland. Electronic address: Valentina.borghesani@nuige.ch.
Ezra MauerMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Department of Psychology, University of California, Berkeley, Berkeley, CA, USA. Electronic address: ezra.mauer@ucsf.edu.
Wendy ShweGeorge Washington University, School of Medicine, Washington, DC, USA. Electronic address: wendy.shwe@gmail.com.
Danielle MizuiriDepartment of Radiology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: Danielle.Mizuiri@ucsf.edu.
Rian BogleyMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Electronic address: Rian.Bogley@ucsf.edu.
Maria Luisa MandelliMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Electronic address: MariaLuisa.Mandelli@ucsf.edu.
Jessica de LeonMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Electronic address: Jessica.deleon@ucsf.edu.
Christa Watson PereiraMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Electronic address: Christa.Watson@ucsf.edu.
Isabel AllenDepartment of Biostatistics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: Isabel.Allen@ucsf.edu.
John HoudeDepartment of Radiology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: john.houde@ucsf.edu.
Joel KramerMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: Joel.Kramer@ucsf.edu.
Bruce L MillerMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Electronic address: Bruce.Miller@ucsf.edu.
Srikantan S NagarajanDepartment of Radiology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: Srikantan.Nagarajan@ucsf.edu.
Maria Luisa Gorno-TempiniMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Electronic address: MariaLuisa.GornoTempini@ucsf.edu.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Multidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
The role of the cerebellum in speechR01DC017091 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John Francis Houde, RICHARD IVRY · 2019 to 2026
$4.5M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Imaging sensorimotor adaptation and compensation of speechR01DC013979 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOUDE, JOHN FRANCIS, NAGARAJAN, SRIKANTAN S. · 2014 to 2018
$1.7M
Role of auditory feedback in speech motor control in Alzheimer's diseaseR01DC017696 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOUDE, JOHN FRANCIS, NAGARAJAN, SRIKANTAN S. · 2018 to 2020
$1.5M
Phenotyping the neural basis of sensorimotor control of speech in 16p11.2 deletion syndromeR01DC021711 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carly Demopoulos, John Francis Houde · 2025 to 2026
$1.4M
Neurodevelopmental Trajectories Towards Neurodegenerative DiseaseK23AG048291 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, ZACHARY A · 2015 to 2019
$912k
NIA NIH HHS K23 AG048291NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG057234NIA NIH HHS T32 AG023481NIDCD NIH HHS K24 DC015544NIDCD NIH HHS R01 DC013979NIDCD NIH HHS R01 DC017091NIDCD NIH HHS R01 DC017696NIDCD NIH HHS R01 DC021711NINDS NIH HHS R01 NS050915NINDS NIH HHS R01 NS100440
6 · The paper itself

Abstract

Based on historic observations that children with reading disabilities were disproportionately both male and non-right-handed, and that early life insults of the left hemisphere were more frequent in boys and non-right-handed children, it was proposed that early focal neuronal injury disrupts typical patterns of motor hand and language dominance and in the process produces developmental dyslexia. To date, these theories remain controversial. We revisited these earliest theories in a contemporary manner, investigating demographics associated with reading disability, and in a subgroup with and without reading disability, compared structural imaging as well as patterns of activity during tasks of verb generation and non-word repetition using magnetoencephalography source imaging. In a large group of healthy aging adults (n = 282; average age 72.3), we assessed reading ability via the Adult Reading History Questionnaire and found that non-right-handedness and male sex significantly predicted endorsed reading disability. In a subset of participants from the larger cohort who endorsed reading disability (n = 14) and a group who denied reading disability (n = 22), we compared structural and functional imaging data. We failed to detect structural differences in volumetric brain morphometry analyses, however we observed decreased neural activity on magnetoencephalography within the reading disability group. The detected differences were largely restricted to left hemisphere ventral occipito-temporal and posterior-lateral temporal cortices, the visual word form area and middle temporal gyrus, regions implicated in developmental dyslexia. Moreover, these observed disruptions occurred in a focal, network-specific manner, preferentially disturbing the ventral/sight reading recognition pathway, resulting in a pattern of regional anomalous lateralization of function that distinguished the reading disability cohort from normal readers. Collectively, the results presented here align with old theories regarding the etiology of developmental dyslexia and highlight how results from investigating neurodevelopmental differences in healthy aging individuals can powerfully contribute towards our overall understanding of neurodevelopment and neurodiversity.

Indexed as

DyslexiaFunctional LateralityOccipital LobeTemporal LobeAdultAgedBrain MappingFemaleHumansMagnetic Resonance ImagingMagnetoencephalographyMaleMiddle AgedReadingAnomalous language lateralizationDyslexiaMagnetoencephalographyNeurodiversityNon-right-handedness

Identifiers

PMID39631179
PMCPMC11936465

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.