Evidence map›Paper›PMID 39630926›Full record

ArticleJournal of chemical information and modeling2024

SmartGraph API: Programmatic Knowledge Mining in Network-Pharmacology Setting.

Gergely Zahoránszky-Kőhalmi, Brandon Walker, Nathan Miller, Brett Yang, Dhatri V L Penna, Jessica Maine, Timothy Sheils, Ke Wang, Jennifer King, Hythem Sidky and 5 more

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gergely Zahoránszky-KőhalmiNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.ORCID 0000-0002-2534-8770
Brandon WalkerNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Nathan MillerNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Brett YangNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Dhatri V L PennaNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Jessica MaineNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Timothy SheilsNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Ke WangNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Jennifer KingNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Hythem SidkyNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Sridhar VuyyuruNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Jeyaraman SoundarajanNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Samuel G MichaelNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Alexander G GodfreyNational Center for Advancing Translational Sciences (NCATS/NIH), 9800 Medical Center Dr., Rockville, Maryland 20850, United States.
Tudor I OpreaDepartment of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, United States.ORCID 0000-0002-6195-6976

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent SmartGraph platform facilitates the execution of complex drug-discovery workflows with ease in the network-pharmacology paradigm. However, at the time of its publication we identified the need for the development of an Application Programming Interface (API) that could promote biomedical data integration and hypothesis generation in an automated manner. This need was magnified at the time of the COVID-19 pandemic. This study addresses the absence of such an API. Accordingly, most functionalities of the original platform were implemented within the SmartGraph API. We demonstrate that by using the API it is possible to transform the original semiautomated workflow behind the Neo4COVID19 database to a fully automated one. The availability of the SmartGraph API lends a significant improvement to the programmatic integration of network-pharmacology-oriented knowledge graphs and analytics, as well as predictive functionalities and workflows.

Indexed as

Data MiningCOVID-19Databases, FactualDrug DiscoveryHumansNetwork PharmacologySARS-CoV-2SoftwareWorkflow

Identifiers

PMID39630926
PMCPMC11683868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.