Evidence map›Paper›PMID 39630924›Full record

ArticleACS infectious diseases2024

Investigating the Translational Value of Periprosthetic Joint Infection Models to Determine the Risk and Severity of Staphylococcal Biofilms.

Amita Sekar, Yingfang Fan, Peyton Tierney, Madeline McCanne, Parker Jones, Fawaz Malick, Devika Kannambadi, Keith K Wannomae, Nicoletta Inverardi, Orhun K Muratoglu and 1 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Epigenetic Mechanisms of Antibiotic Resistance.Current molecular medicine · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Amita SekarHarris Orthopaedics laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.
Yingfang FanHarris Orthopaedics laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.
Peyton TierneyHarris Orthopaedics laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.
Madeline McCanneHarris Orthopaedics laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.
Parker JonesHarris Orthopaedics laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.
Fawaz MalickHarris Orthopaedics laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.
Devika KannambadiHarris Orthopaedics laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.
Keith K WannomaeHarris Orthopaedics laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.
Nicoletta InverardiHarris Orthopaedics laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.ORCID 0000-0003-3550-9299
Orhun K MuratogluHarris Orthopaedics laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.
Ebru OralHarris Orthopaedics laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.ORCID 0000-0001-5761-719X

Funding

Drug-eluting joint implants with synergistic antimicrobial release and risk stratified models of preclinical efficacy testingR01AR077023 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI ORAL, EBRU · 2020 to 2024
$1.8M
NIAMS NIH HHS R01 AR077023
6 · The paper itself

Abstract

With the advent of antibiotic-eluting polymeric materials for targeting recalcitrant infections, using preclinical models to study biofilms are crucial for improving the treatment efficacy in periprosthetic joint infections. The stratification of risk and severity of infections is needed to develop an effective clinical dosing framework with better treatment outcomes. We use in vivo and in vitro implant-associated infection models to demonstrate that methicillin-sensitive and resistant

Indexed as

Anti-Bacterial AgentsBiofilmsDisease Models, AnimalProsthesis-Related InfectionsStaphylococcal InfectionsAnimalsFemaleHumansMethicillin-Resistant Staphylococcus aureusMiceMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial Agentsantibiotic resistancedrug delivery devicesimplant infectionsin vivo modelsStaphylococcus aureus

Identifiers

PMID39630924
PMCPMC12906692

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.